Platelets are not essential for the pulmonary vascular pressor response to hypoxia

Edward K Weir, Jack Seavy, Johannes Mlczoch, Edward Genton, John T. Reeves

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The literature suggests that platelets might help mediate the pulmonary vascular pressor response to hypoxia. This study evaluated the hypoxic response in thrombocytopenic dogs. Platelet depletion was achieved in five dogs by the use of platelet antiserum. In the normoxic state these dogs had lower cardiac outputs and higher pulmonary and systemic vascular resistances than five control dogs. The pressor response to hypoxia in these dogs was not only preserved but considerably enhanced in comparison to the control dogs. Hypoxia increased the pulmonary vascular resistance 146 ± 17 per cent above its normoxic value in the thrombocytopenic dogs and 64 ± 21 per cent in the control dogs. Thus platelets may normally produce a dilator substance or inactivate a pressor substance during hypoxia. The mechanism of this effect is not apparent but it is clear that the pulmonary pressor response to hypoxia in the dog is not mediated by platelets.

Original languageEnglish (US)
Pages (from-to)412-416
Number of pages5
JournalThe Journal of laboratory and clinical medicine
Volume88
Issue number3
StatePublished - Sep 1976

Fingerprint Dive into the research topics of 'Platelets are not essential for the pulmonary vascular pressor response to hypoxia'. Together they form a unique fingerprint.

Cite this