Search everything

Erratum: Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies (AAPS Journal (2006) vol. 8 (1) (E65-E75) 10.1208/aapsj080108)

LeSage, M. G., Keyler, D. E. & Pentel, P. R., Sep 29 2006, In : AAPS Journal. 8, 3, 70.

Research output: Contribution to journalComment/debate

Tobacco Use Disorder
Nicotine
Vaccines
Antibodies
9 Citations (Scopus)

Determination of the in vivo antigen-antibody affinity constant from the redistribution of desipramine in rats following administration of a desipramine-specific monoclonal antibody

Pond, S. M., Pentel, P. R., Keyler, D. E. & Winzor, D. J., Feb 1 1991, In : Biochemical Pharmacology. 41, 3, p. 473-476 4 p.

Research output: Contribution to journalArticle

Antigen-antibody reactions
Desipramine
Regression analysis
Rats
Animals
60 Citations (Scopus)

Effects of continuous nicotine infusion on nicotine self-administration in rats: Relationship between continuously infused and self-administered nicotine doses and serum concentrations

LeSage, M. G., Keyler, D. E., Collins, G. & Pentel, P. R., Nov 1 2003, In : Psychopharmacology. 170, 3, p. 278-286 9 p.

Research output: Contribution to journalArticle

Self Administration
Nicotine
Serum
Cocaine
75 Citations (Scopus)

Reinstatement of nicotine self-administration in rats by presentation of nicotine-paired stimuli, but not nicotine priming

LeSage, M. G., Burroughs, D., Dufek, M., Keyler, D. E. & Pentel, P. R., Nov 1 2004, In : Pharmacology Biochemistry and Behavior. 79, 3, p. 507-513 7 p.

Research output: Contribution to journalArticle

Self Administration
Nicotine
Rats
Light
Light extinction
10 Citations (Scopus)

Effects of pregnancy on nicotine self-administration and nicotine pharmacokinetics in rats

LeSage, M. G., Keyler, D. E., Burroughs, D. & Pentel, P. R., Oct 1 2007, In : Psychopharmacology. 194, 3, p. 413-421 9 p.

Research output: Contribution to journalArticle

Self Administration
Nicotine
Pharmacokinetics
Pregnancy
Third Pregnancy Trimester
35 Citations (Scopus)

Comparison of the behavioral effects of cigarette smoke and pure nicotine in rats

Harris, A. C., Mattson, C., LeSage, M. G., Keyler, D. E. & Pentel, P. R., Aug 1 2010, In : Pharmacology Biochemistry and Behavior. 96, 2, p. 217-227 11 p.

Research output: Contribution to journalArticle

Nicotine
Smoke
Tobacco Products
Rats
Brain
57 Citations (Scopus)

Altered disposition of repeated nicotine doses in rats immunized against nicotine

Keyler, D. E., Hieda, Y., Peter, J. S. & Pentel, P. R., Jan 1 1999, In : Nicotine and Tobacco Research. 1, 3, p. 241-249 9 p.

Research output: Contribution to journalArticle

Nicotine
Brain
Serum
Immunization
Antibodies
2 Citations (Scopus)

Immunological approaches to nicotine addiction

Pentel, P., LeSage, M., Keyler, D. E. & Hatsukami, D., Jan 1 2006, Medication Treatments for Nicotine Dependence. CRC Press, p. 151-166 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Nicotine
Vaccination
Self Administration
Antibodies
Brain
20 Citations (Scopus)

Hypertonic sodium bicarbonate partially reverses QRS prolongation due to flecainide in rats

Keyler, D. E. & Pentel, P. R., 1989, In : Life Sciences. 45, 17, p. 1575-1580 6 p.

Research output: Contribution to journalArticle

Flecainide
Sodium Bicarbonate
Rats
Toxicity
Sodium Channels
11 Citations (Scopus)

Effect of nicotine and tobacco administration method on the mechanical properties of healing bone following closed fracture

Hastrup, S. G., Chen, X., Bechtold, J. E., Kyle, R. F., Rahbek, O., Keyler, D. E., Skoett, M. & Soeballe, K., Sep 1 2010, In : Journal of Orthopaedic Research. 28, 9, p. 1235-1239 5 p.

Research output: Contribution to journalArticle

Closed Fractures
Nicotine
Tobacco
Bone and Bones
Smokeless Tobacco
33 Citations (Scopus)

Combined active and passive immunization enhances the efficacy of immunotherapy against nicotine in rats

Roiko, S. A., Harris, A. C., Keyler, D. E., LeSage, M. G., Zhang, Y. & Pentel, P. R., Jun 1 2008, In : Journal of Pharmacology and Experimental Therapeutics. 325, 3, p. 985-993 9 p.

Research output: Contribution to journalArticle

Passive Immunization
Nicotine
Immunotherapy
Vaccination
Serum
4 Citations (Scopus)

Effects of alpha-1-acid glycoprotein administration on propranolol binding and beta blockade in rats

Keyler, D. E. & Pentel, P. R., Apr 1 1989, In : Biochemical Pharmacology. 38, 7, p. 1163-1168 6 p.

Research output: Contribution to journalArticle

Orosomucoid
Propranolol
Rats
Serum
Albumins
21 Citations (Scopus)

Drug-specific F(ab′)2 fragment reduces desipramine cardiotoxicity in rats

Brunn, G. J., Keyler, D. E., Ross, C. A., Pond, S. M. & Pentel, P. R., 1991, In : International Journal of Immunopharmacology. 13, 7, p. 841-851 11 p.

Research output: Contribution to journalArticle

Desipramine
Tricyclic Antidepressive Agents
Pharmaceutical Preparations
Immunoglobulin Fragments
Cardiotoxicity
48 Citations (Scopus)

Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies

LeSage, M. G., Keyler, D. E. & Pentel, P. R., Feb 24 2006, In : AAPS Journal. 8, 1, 8.

Research output: Contribution to journalReview article

Tobacco Use Disorder
Nicotine
Vaccines
Antibodies
Clinical Trials, Phase I
8 Citations (Scopus)

Glutaramyl-β-alanyl Spacer Group for Haptenic Coupling to Proteins. Preparation of Immunogens for Antibody Production against Polychlorinated Biphenyls

Goon, D. J. W., Nagasawa, H. T., Keyler, D. E., Ross, C. A. & Pentel, P. R., Sep 1 1994, In : Bioconjugate Chemistry. 5, 5, p. 418-422 5 p.

Research output: Contribution to journalArticle

Haptens
Polychlorinated Biphenyls
Polychlorinated biphenyls
Antibodies
Antibody Formation
15 Citations (Scopus)

Composition, red blood cell uptake, and serum protein binding of phytoestrogens extracted from commercial kudzu-root and soy preparations

Benlhabib, E., Baker, J. I., Keyler, D. E. & Singh, A. K., Jan 1 2002, In : Journal of Medicinal Food. 5, 3, p. 109-123 15 p.

Research output: Contribution to journalArticle

Pueraria
Phytoestrogens
Protein Binding
Blood Proteins
Erythrocytes
21 Citations (Scopus)

Quantitative analysis of phytoestrogens in kudzu-root, soy and spiked serum samples by high-pressure liquid chromatography

Benlhabib, E., Baker, J. I., Keyler, D. E. & Singh, A. K., Jul 1 2004, In : Biomedical Chromatography. 18, 6, p. 367-380 14 p.

Research output: Contribution to journalArticle

Pueraria
High pressure liquid chromatography
Phytoestrogens
High Pressure Liquid Chromatography
Glycosides
21 Citations (Scopus)

Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: Time course and influence of nicotine dosing regimen

Keyler, D. E., Dufek, M. B., Calvin, A. D., Bramwell, T. J., LeSage, M. G., Raphael, D. E., Ross, C. A., Le, C. T. & Pentel, P. R., May 1 2005, In : Biochemical Pharmacology. 69, 9, p. 1385-1395 11 p.

Research output: Contribution to journalArticle

Nicotine
Rats
Brain
Vaccination
Mothers
18 Citations (Scopus)

Rapid administration of high-dose human antibody fab fragments to dogs: Pharmacokinetics and toxicity

Keyler, D. E., Salerno, D. M., Murakami, M. M., Ruth, G. & Pentel, P. R., Jul 1 1991, In : Toxicological Sciences. 17, 1, p. 83-91 9 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Immunoglobulin Fab Fragments
Pharmacokinetics
Toxicity
Dogs
24 Citations (Scopus)

Reduction of Desipramine Cardiotoxicity and Prolongation of Survival in Rats With the Use of Polyclonal Drug-Specific Antibody Fab Fragments

Pentel, P. R., Scarlett, W., Ross, C. A., Landon, J., Sidki, A. & Keyler, D. E., Sep 1995, In : Annals of Emergency Medicine. 26, 3, p. 334-341 8 p.

Research output: Contribution to journalArticle

Immunoglobulin Fragments
Immunoglobulin Fab Fragments
Desipramine
Pharmaceutical Preparations
Cardiotoxicity
39 Citations (Scopus)

Inhibition of nicotine-induced seizures in rats by combining vaccination against nicotine with chronic nicotine infusion

Tuncok, Y., Hieda, Y., Keyler, D. E., Brown, S., Ennifar, S., Fattom, A. & Pentel, P. R., Sep 27 2001, In : Experimental and Clinical Psychopharmacology. 9, 2, p. 228-234 7 p.

Research output: Contribution to journalArticle

Nicotine
Vaccination
Seizures
Vaccines
Subcutaneous Infusions

Current status of immunologic approaches to treating tobacco dependence: Vaccines and nicotine-specific antibodies

LeSage, M. G., Keyler, D. E. & Pentel, P. R., Dec 1 2008, Drug Addiction: From Basic Research to Therapy. Springer New York, p. 455-475 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tobacco Use Disorder
Nicotine
Vaccines
Antibodies
Clinical Trials, Phase I
57 Citations (Scopus)

Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats

LeSage, M. G., Keyler, D. E., Hieda, Y., Collins, G., Burroughs, D., Le, C. & Pentel, P. R., Feb 1 2006, In : Psychopharmacology. 184, 3-4, p. 409-416 8 p.

Research output: Contribution to journalArticle

Conjugate Vaccines
Self Administration
Nicotine
Maintenance
Vaccination
24 Citations (Scopus)

Passive immunization with a nicotine-specific monoclonal antibody decreases brain nicotine levels but does not precipitate withdrawal in nicotine-dependent rats

Roiko, S. A., Harris, A. C., LeSage, M. G., Keyler, D. E. & Pentel, P. R., Aug 1 2009, In : Pharmacology Biochemistry and Behavior. 93, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

Immunization
Passive Immunization
Nicotine
Rats
Precipitates
10 Citations (Scopus)

Effects of nicotine infusion on the metabolism of the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rats

Keyler, D., Pentel, P. R., Kuehl, G., Collins, G. & Murphy, S. E., Dec 8 2003, In : Cancer Letters. 202, 1, p. 1-9 9 p.

Research output: Contribution to journalArticle

Nicotine
Carcinogens
Tobacco
Hydroxylation
Nitrosamines
20 Citations (Scopus)

Reversal of flecainide-induced ventricular arrhythmia by hypertonic sodium bicarbonate in dogs

Salerno, D. M., Murakami, M. M., Johnston, R. B., Keyler, D. E. & Pentel, P. R., Jan 1 1995, In : American Journal of Emergency Medicine. 13, 3, p. 285-293 9 p.

Research output: Contribution to journalArticle

Flecainide
Sodium Bicarbonate
Cardiac Arrhythmias
Dogs
Ventricular Tachycardia
50 Citations (Scopus)

Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats

Cao, J., Belluzzi, J. D., Loughlin, S. E., Keyler, D. E., Pentel, P. R. & Leslie, F. M., Sep 1 2007, In : Neuropsychopharmacology. 32, 9, p. 2025-2035 11 p.

Research output: Contribution to journalArticle

Acetaldehyde
Nicotine
Smoke
Tobacco
Corticosterone
9 Citations (Scopus)

Pretreatment with drug-specific antibody reduces desipramine cardiotoxicity in rats

Pentel, P. R., Brunn, G. J., Pond, S. M. & Keyler, D. E., 1991, In : Life Sciences. 48, 7, p. 675-683 9 p.

Research output: Contribution to journalArticle

Desipramine
Rats
Antibodies
Animals
Pharmaceutical Preparations
40 Citations (Scopus)

Kudzu root extract suppresses voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol

Benlhabib, E., Baker, J. I., Keyler, D. E. & Singh, A. K., Jun 1 2004, In : Journal of Medicinal Food. 7, 2, p. 168-179 12 p.

Research output: Contribution to journalArticle

Pueraria
Substance Withdrawal Syndrome
Alcohols
Water
Alcohol Drinking
53 Citations (Scopus)

Effects of purified puerarin on voluntary alcohol intake and alcohol withdrawal symptoms in P rats receiving free access to water and alcohol

Benlhabib, E., Baker, J. I., Keyler, D. E. & Singh, A. K., Jun 1 2004, In : Journal of Medicinal Food. 7, 2, p. 180-186 7 p.

Research output: Contribution to journalArticle

Substance Withdrawal Syndrome
Alcohols
Water
Isoflavones
puerarin
19 Citations (Scopus)

Stability of heroin, 6-monoacetylmorphine, and morphine in biological samples and validation of an LC-MS assay for delayed analyses of pharmacokinetic samples in rats

Jones, J. M., Raleigh, M. D., Pentel, P. R., Harmon, T. M., Keyler, D. E., Remmel, R. P. & Birnbaum, A. K., Feb 3 2013, In : Journal of Pharmaceutical and Biomedical Analysis. 74, p. 291-297 7 p.

Research output: Contribution to journalArticle

Pharmacokinetics
Heroin
Morphine
Rats
Assays
15 Citations (Scopus)

Effects of recombinant drug-specific single chain antibody Fv fragment on [3H]-desipramine distribution in rats

Shelver, W. L., Keyler, D. E., Lin, G., Murtaugh, M. P., Flickinger, M. C., Ross, C. A. & Pentel, P. R., Feb 23 1996, In : Biochemical Pharmacology. 51, 4, p. 531-537 7 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Desipramine
Rats
Immunoglobulin Fab Fragments
Pharmaceutical Preparations
16 Citations (Scopus)

Drug-specific antibodies as antidotes for tricyclic antidepressant overdose

Pentel, P. R. & Keyler, D. E., Jan 1 1995, In : Toxicology Letters. 82-83, C, p. 801-806 6 p.

Research output: Contribution to journalArticle

Antidotes
Tricyclic Antidepressive Agents
Desipramine
Antibodies
Pharmaceutical Preparations
4 Citations (Scopus)

Bacterial expression and characterization of an anti-desipramine single-chain antibody fragment

Lin, G., Pentel, P. R., Shelver, W. L., Keyler, D. E., Ross, C. A., Hieda, Y., Flickinger, M. C., Pennell, C. A. & Murtaugh, M. P., Jan 1 1996, In : International Journal of Immunopharmacology. 18, 12, p. 729-738 10 p.

Research output: Contribution to journalArticle

Single-Chain Antibodies
Immunoglobulin Fragments
Desipramine
Tricyclic Antidepressive Agents
Drug Overdose
2 Citations (Scopus)

Effect of calcium chloride and 4-aminopyridine therapy on desipramine toxicity in rats

Wananukul, W., Keyler, D. E. & Pentel, P. R., Jan 1 1996, In : Journal of Toxicology - Clinical Toxicology. 34, 5, p. 499-506 8 p.

Research output: Contribution to journalArticle

4-Aminopyridine
Calcium Chloride
Desipramine
Tricyclic Antidepressive Agents
Toxicity
17 Citations (Scopus)

Combined active and passive immunization against nicotine: Minimizing monoclonal antibody requirements using a target antibody concentration strategy

Cornish, K. E., Harris, A. C., Lesage, M. G., Keyler, D. E., Burroughs, D., Earley, C. & Pentel, P. R., Nov 1 2011, In : International Immunopharmacology. 11, 11, p. 1809-1815 7 p.

Research output: Contribution to journalArticle

Passive Immunization
Nicotine
Vaccination
Monoclonal Antibodies
Antibodies