We report on scalable and position-controlled optical nanoprobe arrays using ZnO nanotube waveguides on graphene films for use in local optical excitation. For the waveguide fabrication, position-controlled and well-ordered ZnO nanotube arrays were grown on chemical vapor deposited graphene films with a submicron patterned mask layer and Au prepared between the interspace of nanotubes. Mammalian cells were cultured on the nanotube waveguide arrays and were locally excited by light illuminated through the nanotubes. Fluorescence and optogenetic signals could be excited through the optical nanoprobes. This method offers the ability to investigate cellular behavior with a high spatial resolution that surpasses the current limitation.
Bibliographical noteFunding Information:
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science, ICT and Future Planning (MSIP) (Nos. NRF-2015K1A1A2033332, NRF-2014M3A7B4051596, and NRF-2015R1A5A1037627), and by the SNU-Yonsei Research Cooperation Program through Seoul National University (SNU) in 2016. It was also supported by grants from CAMP funded by the Ministry of Science and Technology (RIAM) and from the Korea Research Foundation. H. Y. Park acknowledges support from the Basic Science Research Program through the NRF funded by the Ministry of Science, ICT and Future Planning (No. 2015R1C1A1A02036674).
© 2017 Author(s).