'Zip codes' direct intracellular protein tyrosine phosphatases to the correct cellular 'address'

Laura J. Mauro, Jack E. Dixon

Research output: Contribution to journalArticle

178 Scopus citations

Abstract

The transmembrane and intracellular protein tyrosine phosphatases (PTPs) play an essential role as signal transduction proteins involved in various cellular processes including division, proliferation and differentiation. As such, their activity must be strictly regulated to avoid nonspecific tyrosine dephosphorylation of cellular proteins. The intracellular PTPs possess a diversity of protein sequences outside the catalytic domain that appear to serve as 'zip codes' specifically 'addressing' these proteins to defined subcellular compartments. These localization strategies are proposed to function as a regulatory mechanism, defining the substrate specificity and function of the intracellular PTPs.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalTrends in Biochemical Sciences
Volume19
Issue number4
DOIs
StatePublished - Apr 1994

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