Zinc and Metallothionein in the Development and Progression of Dental Caries

Mohammad Tariqur Rahman, Ashfaque Hossain, Chew Hooi Pin, Noor Azlin Yahya

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations


Chronic oxidative stress and reactive oxygen species (ROS) in oral cavity as well as acidic pH on dental enamel surface due to the metabolic activities of bacterial plaque are the major contributors in the development and progression of dental caries. Along with other factors, deposition or dissolution Ca and Mg mostly determines the re- or demineralization of dental enamel. Zn plays an important role for both Ca and Mg bioavailability in oral cavity. Metallothionein (MT), a group of small molecular weight, cysteine-rich proteins (~ 7 kDa), is commonly induced by ROS, bacterial infection, and Zn. In the current review, we evaluated MT at the junction between the progression of dental caries and its etiologies that are common in MT biosynthesis.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalBiological Trace Element Research
Issue number1
StatePublished - Jan 1 2019


  • Calcium
  • Dental caries
  • Magnesium
  • Metallothionein
  • Reactive oxygen species
  • Zinc

PubMed: MeSH publication types

  • Journal Article
  • Review


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