TY - JOUR
T1 - Zinc and Metallothionein in the Development and Progression of Dental Caries
AU - Rahman, Mohammad Tariqur
AU - Hossain, Ashfaque
AU - Pin, Chew Hooi
AU - Yahya, Noor Azlin
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Chronic oxidative stress and reactive oxygen species (ROS) in oral cavity as well as acidic pH on dental enamel surface due to the metabolic activities of bacterial plaque are the major contributors in the development and progression of dental caries. Along with other factors, deposition or dissolution Ca and Mg mostly determines the re- or demineralization of dental enamel. Zn plays an important role for both Ca and Mg bioavailability in oral cavity. Metallothionein (MT), a group of small molecular weight, cysteine-rich proteins (~ 7 kDa), is commonly induced by ROS, bacterial infection, and Zn. In the current review, we evaluated MT at the junction between the progression of dental caries and its etiologies that are common in MT biosynthesis.
AB - Chronic oxidative stress and reactive oxygen species (ROS) in oral cavity as well as acidic pH on dental enamel surface due to the metabolic activities of bacterial plaque are the major contributors in the development and progression of dental caries. Along with other factors, deposition or dissolution Ca and Mg mostly determines the re- or demineralization of dental enamel. Zn plays an important role for both Ca and Mg bioavailability in oral cavity. Metallothionein (MT), a group of small molecular weight, cysteine-rich proteins (~ 7 kDa), is commonly induced by ROS, bacterial infection, and Zn. In the current review, we evaluated MT at the junction between the progression of dental caries and its etiologies that are common in MT biosynthesis.
KW - Calcium
KW - Dental caries
KW - Magnesium
KW - Metallothionein
KW - Reactive oxygen species
KW - Zinc
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U2 - 10.1007/s12011-018-1369-z
DO - 10.1007/s12011-018-1369-z
M3 - Review article
C2 - 29744817
AN - SCOPUS:85046696916
SN - 0163-4984
VL - 187
SP - 51
EP - 58
JO - Biological Trace Element Research
JF - Biological Trace Element Research
IS - 1
ER -