ZAP-70: an essential kinase in T-cell signaling.

Haopeng Wang, Theresa A. Kadlecek, Byron B. Au-Yeung, Hanna E.Sjölin Goodfellow, Lih Yun Hsu, Tanya S. Freedman, Arthur Weiss

Research output: Contribution to journalReview article

180 Scopus citations

Abstract

ZAP-70 is a cytoplasmic protein tyrosine kinase that plays a critical role in the events involved in initiating T-cell responses by the antigen receptor. Here we review the structure of ZAP-70, its regulation, its role in development and in disease. We also describe a model experimental system in which ZAP-70 function can be interrupted by a small chemical inhibitor.

Original languageEnglish (US)
Pages (from-to)a002279
JournalCold Spring Harbor Perspectives in Biology
Volume2
Issue number5
DOIs
StatePublished - May 1 2010

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    Wang, H., Kadlecek, T. A., Au-Yeung, B. B., Goodfellow, H. E. S., Hsu, L. Y., Freedman, T. S., & Weiss, A. (2010). ZAP-70: an essential kinase in T-cell signaling. Cold Spring Harbor Perspectives in Biology, 2(5), a002279. https://doi.org/10.1101/cshperspect.a002279