Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents

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Abstract

Background: The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. Methods: Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4±3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. Results: Using GLM regression, age (β=0.03, P=0.014) and SBP (β=0.015, P=0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β=0.025, P=0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. Conclusion: Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.

Original languageEnglish (US)
Pages (from-to)410-414
Number of pages5
JournalAtherosclerosis
Volume234
Issue number2
DOIs
StatePublished - Jan 1 2014

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Dilatation
Hyperemia
Fingers
Blood Pressure
Body Mass Index
Weights and Measures
Brachial Artery
Ultrasonography

Keywords

  • Adolescents
  • Children
  • Endothelial function
  • Flow-mediated dilation
  • Reactive hyperemic index

Cite this

@article{754f50d17eb24199a927ce21d75ceb4b,
title = "Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents",
abstract = "Background: The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. Methods: Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4±3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. Results: Using GLM regression, age (β=0.03, P=0.014) and SBP (β=0.015, P=0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β=0.025, P=0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. Conclusion: Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.",
keywords = "Adolescents, Children, Endothelial function, Flow-mediated dilation, Reactive hyperemic index",
author = "Kelly, {Aaron S} and Marlatt, {Kara L.} and Julia Steinberger and Dengel, {Donald R}",
year = "2014",
month = "1",
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doi = "10.1016/j.atherosclerosis.2014.03.031",
language = "English (US)",
volume = "234",
pages = "410--414",
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TY - JOUR

T1 - Younger age is associated with lower reactive hyperemic index but not lower flow-mediated dilation among children and adolescents

AU - Kelly, Aaron S

AU - Marlatt, Kara L.

AU - Steinberger, Julia

AU - Dengel, Donald R

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. Methods: Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4±3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. Results: Using GLM regression, age (β=0.03, P=0.014) and SBP (β=0.015, P=0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β=0.025, P=0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. Conclusion: Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.

AB - Background: The use of digital reactive hyperemia as a measure of endothelial function among children and adolescents is becoming increasingly common. However, unexpected observations of low reactive hyperemic index values in younger children in our laboratory led us to conduct a study evaluating the influence of age, sex, height, weight, blood pressure, body mass index (BMI), and finger volume on RHI values. Methods: Endothelial function, measured by digital reactive hyperemia (reactive hyperemic index: RHI) was assessed in 113 children and adolescents (mean age 12.4±3.8 years; 64 males), with 102 also assessed for brachial artery flow-mediated dilation (FMD) using ultrasound imaging. Associations with age, sex, height, weight, systolic and diastolic blood pressure (SBP, DBP), BMI, and finger volume were evaluated. Results: Using GLM regression, age (β=0.03, P=0.014) and SBP (β=0.015, P=0.004) were significantly associated with RHI. No measures were associated with FMD. In the subset of individuals with measured finger volume, age (β=0.025, P=0.037) was the only measure significantly associated with log RHI. Similarly, no measures were associated with FMD. Conclusion: Younger age is associated with lower RHI but not lower FMD among children and adolescents. These findings call into question the validity and usefulness of digital reactive hyperemia as a method to quantify endothelial function among younger children.

KW - Adolescents

KW - Children

KW - Endothelial function

KW - Flow-mediated dilation

KW - Reactive hyperemic index

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