Yes-associated protein-1 may serve as a diagnostic marker and therapeutic target for residual/recurrent hepatocellular carcinoma post-transarterial chemoembolization

Qian Xia Qian, Wei Zhang, Alireza Shams, Kahee Mohammed, Alex S. Befeler, Ningling Kang, Jinping Lai

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background and aim: The transcriptional co-activator Yes-associated protein-1 (YAP1) has been implicated as an oncogene and is overexpressed in different kinds of human cancers, especially hepatocellular carcinoma (HCC). However, the role of YAP1 has not been reported in residual/recurrent HCC after transarterial chemoembolization (TACE). Our aim is to determine whether YAP1 is overexpressed in the residual/recurrent HCC after TACE. Methods: A total of 105 tumor tissues from 71 patients including 30 cases of primary HCC without prior treatment, 35 cases of residual/recurrent HCC post TACE, and 6 cases of hepatoblastoma were included in the immunohistochemical study. YAP1 immunoreactivity was blindly scored as 0, 1+, 2+ or 3+ in density and percentages of positive cells. Results: About 33.3% (10/30) of primary HCC without prior treatment showed 2+ of YAP1 immunoreactivity. While 82.8% (29/35) of residual/recurrent HCCs after TACE treatment displayed 2–3+ of YAP1 immunoreactivity, which was significantly higher compared to primary HCC without prior treatment (P = 0.0002). YAP1 immunoreactivity was moderately to strongly positive (2–3+) in 100% of the hepatoblastoma, particularly in the embryonal components (3+ in 100% cases). Conclusions: YAP1 is significantly upregulated in the residual/recurrent HCCs post TACE treatment, suggesting that YAP1 may serve as a sensitive diagnostic marker and a treatment target for residual/recurrent HCC post TACE.

Original languageEnglish (US)
Pages (from-to)212-217
Number of pages6
JournalLiver Research
Volume4
Issue number4
DOIs
StatePublished - Dec 2020

Bibliographical note

Funding Information:
This study was supported by the USA National Institutes of Health grant R01 CA187027 (to N. Kang).

Publisher Copyright:
© 2020 The Third Affiliated Hospital of Sun Yat-sen University

Keywords

  • Cancer stem cell (CSC)
  • Hepatoblastoma
  • Immunohistochemistry
  • Residual/recurrent hepatocellular carcinoma
  • Transarterial chemoembolization (TACE)
  • Yes-associated protein-1 (YAP1)

PubMed: MeSH publication types

  • Journal Article

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