Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs

Daniel J. Garry; Joshua I. Weiner; Sarah M. Greising; David H. Sachs; Mary G. Garry

doi:10.1111/xen.12786

Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs

Daniel J. Garry, Joshua I. Weiner, Sarah M. Greising, David H. Sachs, Mary G. Garry

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.

Original language	English (US)
Article number	e12786
Journal	Xenotransplantation
Volume	30
Issue number	1
DOIs	https://doi.org/10.1111/xen.12786
State	Published - Jan 1 2023

Bibliographical note

Funding Information:
Authors acknowledge grant funding from the Department of Defense (grant no. W81XWH2020047) and the NHLBI (grant no. HL144582).

Publisher Copyright:
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Keywords

ETV2
MYOD family
blastocyst complementation
skeletal muscle
xenotransplantation

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/xen.12786

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title = "Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs",

abstract = "Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.",

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AU - Greising, Sarah M.

AU - Sachs, David H.

AU - Garry, Mary G.

N1 - Funding Information: Authors acknowledge grant funding from the Department of Defense (grant no. W81XWH2020047) and the NHLBI (grant no. HL144582). Publisher Copyright: © 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.

AB - Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.

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KW - MYOD family

KW - blastocyst complementation

KW - skeletal muscle

KW - xenotransplantation

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ER -

Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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