Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.
Bibliographical noteFunding Information:
Authors acknowledge grant funding from the Department of Defense (grant no. W81XWH2020047) and the NHLBI (grant no. HL144582).
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
- MYOD family
- blastocyst complementation
- skeletal muscle
PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
- Research Support, U.S. Gov't, Non-P.H.S.