Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs

Daniel J. Garry, Joshua I. Weiner, Sarah M. Greising, David H. Sachs, Mary G. Garry

Research output: Contribution to journalComment/debatepeer-review


Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.

Original languageEnglish (US)
Article numbere12786
Issue number1
StatePublished - Jan 1 2023

Bibliographical note

Funding Information:
Authors acknowledge grant funding from the Department of Defense (grant no. W81XWH2020047) and the NHLBI (grant no. HL144582).

Publisher Copyright:
© 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.


  • ETV2
  • MYOD family
  • blastocyst complementation
  • skeletal muscle
  • xenotransplantation

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.


Dive into the research topics of 'Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs'. Together they form a unique fingerprint.

Cite this