X-ray structure, solution properties, and biological activity profile of vanadocene(IV) acetylacetonate complex, [VCp2(acac)](CF3SO3): A dual-function anti-cancer agent with anti-angiogenic and anti-mitotic properties

Phalguni Ghosh, Sutapa Ghosh, Christopher Navara, Rama Krishna Narla, Alexey Benyumov, Fatih M. Uckun

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The structure of [V(η5-C5H5)2(CH 3C(O)CHC(O)CH3)](O3SCF3) (1) (=[VCp2(acac)](O3SCF3)), a dual-function anti-cancer agent with anti-angiogenic and anti-mitotic properties, was determined by single-crystal X-ray diffraction. The geometry is well described as a pseudo-tetrahedral like structure with the centroids of the cyclopentadienyl rings and the two oxygen atoms of the acetylacetonate ring in the ancillary positions of the central vanadium (IV) atom. The bisector of the V(acac) fragment deviates from the C2 axis of the ligand framework by only 4°, compared to a deviation of 7° for the V(acac) fragment in the tetramethylethano-bridged vanadocene acetyl acetonate complex. Crystal data for 1: space group, P21/c; a = 7.5544(9) Å, b = 14.936(2) Å, c = 16.193(2) Å, β = 102.901(2)°, V = 1781.0(4) Å3; Z = 4; R = 0.0506 for 2310 reflections with I > 2σ(I). This report also details the electron paramagnetic resonance, UV/Vis spectroscopy, electrochemical properties and the biological activity profile of this potent anti-cancer agent.

Original languageEnglish (US)
Pages (from-to)241-253
Number of pages13
JournalJournal of Inorganic Biochemistry
Volume84
Issue number3-4
DOIs
StatePublished - 2001

Bibliographical note

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Angiogenesis
  • Cancer
  • Vanadocene
  • X-ray

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