X-irradiation chronosensitivity and circadian rhythmic proliferation in healthy and sarcoma-carrying rats' bone marrow

M. A. Blank, V. A. Gushchin, F. Halberg, A. Portela, Germaine G Cornelissen-Guillaume

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Mitotic activity of bone marrow and tumor of sarcoma-bearing rats and of bone marrow of healthy controls is circadian periodic. Whereas the circadian rhythm in mitotic activity of bone marrow is similar for intact and tumor bearing rats, with a peak occurring shortly after the onset of the dark (activity) span, the circadian rhythm in mitotic activity of tumor has a much smaller amplitude and a different acrophase occuring late in the dark span. This difference in acrophase of mitotic activity of bone marrow and tumor has important implications for scheduling the administration of oncotherapy. For the tumor model examined herein, it suggests the possibility to achieve concomitantly near maximal efficacy and near minimal myelotoxicity, a result awaiting further investigation in humans with different kinds of malignancies.

Original languageEnglish (US)
Pages (from-to)395-400
Number of pages6
JournalIn Vivo
Volume9
Issue number4
StatePublished - 1995

Bibliographical note

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

  • Bone marrow
  • Chronobiology
  • Circadian rhythmic proliferation
  • Rat sarcoma
  • X-irradiation

Fingerprint Dive into the research topics of 'X-irradiation chronosensitivity and circadian rhythmic proliferation in healthy and sarcoma-carrying rats' bone marrow'. Together they form a unique fingerprint.

Cite this