TY - JOUR
T1 - Wound infections
AU - Sawyer, R. G.
AU - Pruett, T. L.
PY - 1994
Y1 - 1994
N2 - Wound infections continue to be an important entity in terms of use of time and medical resources. Currently, the following risk factors are known to strongly predispose to wound infection: pre-existing medical illness, prolonged operative time, wound contamination, and contaminated or dirty wounds. Tissue level factors, including the local microenvironment, white cells, and cellular products that mediate inflammation, are important, and their manipulation holds promise for future therapies. For now, the judicious use of antibiotic prophylaxis and organized systems of wound surveillance are the most effective means to reduce the wound infection rate to its pathophysiologically attainable minimum.
AB - Wound infections continue to be an important entity in terms of use of time and medical resources. Currently, the following risk factors are known to strongly predispose to wound infection: pre-existing medical illness, prolonged operative time, wound contamination, and contaminated or dirty wounds. Tissue level factors, including the local microenvironment, white cells, and cellular products that mediate inflammation, are important, and their manipulation holds promise for future therapies. For now, the judicious use of antibiotic prophylaxis and organized systems of wound surveillance are the most effective means to reduce the wound infection rate to its pathophysiologically attainable minimum.
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U2 - 10.1016/s0039-6109(16)46327-9
DO - 10.1016/s0039-6109(16)46327-9
M3 - Review article
C2 - 8197528
AN - SCOPUS:0028271179
SN - 0039-6109
VL - 74
SP - 519
EP - 536
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
IS - 3
ER -