Worldwide Network for Blood and Marrow Transplantation Recommendations for Establishing a Hematopoietic Cell Transplantation Program, Part I: Minimum Requirements and Beyond

Marcelo C. Pasquini, Alok Srivastava, Syed Osman Ahmed, Mahmoud Aljurf, Yoshiko Atsuta, Carol Doleysh, Sebastian Galeano, Eliane Gluckman, Hildegard Greinix, Gregory A. Hale, Parameswaran Hari, Shahrukh K. Hashmi, Naynesh Kamani, Mary J. Laughlin, Dietger Niederwieser, Adriana Seber, Jeffrey Szer, John A. Snowden, Koen Van Biesen, Paula WatryDaniel J. Weisdorf, Jane Apperley

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Hematopoietic cell transplantation (HCT) is a highly complex procedure that requires a dedicated multidisciplinary team to optimize safety. In addition, institutions may have different needs regarding indications based on regional disease prevalence or may have an interest in developing specialized services. Structured recommendations are not commonly available, however. The Transplant Center and Recipient Issues Standing Committee of the Worldwide Network for Blood and Marrow Transplantation (WBMT) organized a structured review of all pertinent elements for establishing a transplantation program. First, we solicited components from committee members and grouped them into domains (infrastructure, staff, cell processing laboratory, blood banking, laboratory, radiology, pharmacy, HLA testing, ancillary services, and quality). Subsequently, reviewers scored each element on a 7-point scale, ranging from an absolute requirement (score of 1) to not required (score of 7). An independent group of 5 experienced transplantation physicians reviewed the rankings. The minimum requirements for establishing any HCT program were identified among elements with mean score of ≤2.0, and specific elements for allogeneic and autologous HCT were identified. Mean scores of >2.0 to 4.0 were classified as preferred recommendation, and mean scores of >4.0 to ≤ 7.0 were considered ideal recommendations for advanced and complex types of transplantation. This structured set of recommendations guides the prioritization of minimum requirements to establish a transplantation program and set the stage for expansion and further development.

Original languageEnglish (US)
Pages (from-to)2322-2329
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Issue number12
StatePublished - Dec 2019

Bibliographical note

Funding Information:
The authors thank Carol Doleysh for assistance in organizing the data and Jennifer Motl for editorial support, which was funded by the Medical College of Wisconsin in accordance with Good Publication Practice (GPP3) guidelines ( ). The authors also acknowledge Eoin McGrath, JACIE Operations Manager, for reviewing and providing input on the manuscript.

Publisher Copyright:
© 2019 American Society for Transplantation and Cellular Therapy


  • Autologous versus allogeneic transplantation
  • Transplantation program requirements


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