Working harder to stay alive: Metabolic rate increases with age in Drosophila simulans but does not correlate with life span

Richard G. Melvin, Wayne A. Van Voorhies, J. William O. Ballard

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The hypothesis that metabolic rate is inversely correlated with life span has long been debated. Another area of controversy has been the relationship between metabolic rate and aging. In most molecular studies key aspects of cellular metabolism have been shown to decline with age. Less attention has been focused on metabolic rate as an organism ages. We studied the survival of three Drosophila simulans fly lines and measured whole organism metabolic rate, mitochondrial DNA copy number and walking speed. Metabolic rate as assayed by CO2 production did not correlate with median lifespan but increased by 0.43-1.14%/d. In contrast, mitochondrial DNA copy number decreased by 0.56-1.06%/d. Physical activity, as assayed by mean walking speed, did not change with age but was positively correlated with mitochondrial DNA copy number. One explanation for these data is that metabolic rate was increased, in the face of a reduced mitochondrial DNA copy number and capacity for oxidative metabolism, to maintain a constant bioenergetic demand (physical activity). Alternatively, metabolic rate may increase to provide energy for the repair of cellular damage or due to a shift in metabolic substrate use over time.

Original languageEnglish (US)
Pages (from-to)1300-1306
Number of pages7
JournalJournal of Insect Physiology
Volume53
Issue number12
DOIs
StatePublished - Dec 2007
Externally publishedYes

Bibliographical note

Funding Information:
We thank J.B. Williams for discussion and comments on the manuscript. S. Katewa and I. Ricafuente provided laboratory assistance. Three anonymous reviewers made constructive comments. Funds were provided by National Science Foundation Grant DEB-0444766, and National Institutes of Health RO1 grant GM067862-01 to JWOB and a National Cancer Institute MSI CCP NCI U56 CA96286 to W.V.V.

Keywords

  • Aging
  • Life span
  • Metabolic rate
  • Oxidative phosphorylation
  • mtDNA

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