Within the cell: Analytical techniques for subcellular analysis

Karen J. Olson, Hossein Ahmadzadeh, Edgar A. Arriaga

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

This review covers recent developments in the preparation, manipulation, and analyses of subcellular environments. In particular, it highlights approaches for (1) separation and detection of individual organelles, (2) preparation of ultra-pure organelle fractions, and (3) utilization of novel labeling strategies. These approaches, based on innovative technologies such as microfluidics, immunoisolation, mass spectrometry and electrophoresis, suggest that subcellular analyses will soon become as commonplace as single cell and bulk cellular assays.

Original languageEnglish (US)
Pages (from-to)906-917
Number of pages12
JournalAnalytical and Bioanalytical Chemistry
Volume382
Issue number4
DOIs
StatePublished - Jun 1 2005

Keywords

  • Electrophoresis
  • Flow cytometry
  • Organelle
  • Subcellular analysis

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