Wilson's disease with and without rapid eye movement sleep behavior disorder compared to healthy matched controls

Gotthard G. Tribl, Mateus C. Trindade, Thais Bittencourt, Geraldo Lorenzi-Filho, Rosana Cardoso Alves, Daniel Ciampi de Andrade, Erich T. Fonoff, Edson Bor-Seng-Shu, Alexandre A. Machado, Carlos H. Schenck, Manoel J. Teixeira, Egberto R. Barbosa

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Objective: Quantitative data are reported on rapid eye movement (REM) sleep behavior disorder (RBD) in a cohort of predominantly neurological Wilson's disease (WD). Methods: A total of 41 patients with WD and 41 healthy, age- and gender-matched controls were studied by conducting face-to-face interviews, neurological and clinical examinations, laboratory tests, and WD- and RBD-specific scales. Video-polysomnography and quantification of REM sleep without atonia (RWA) were conducted in 35 patients and 41 controls. Results: Patients with WD showed significantly worse sleep quality, less sleep efficiency, increased wakefulness after sleep onset, and more arousals compared to healthy controls. Five patients with WD (four women) fulfilled the diagnostic criteria for RBD with significantly higher values in RWA, RBD Questionnaire-Hong Kong, and RBD Screening Questionnaire compared to patients with WD without RBD. In three patients with WD, RBD had manifested before any other symptom that could be attributed to WD. Percentage of RWA was significantly lower in WD without RBD than in WD with RBD, but still significantly increased compared to controls. Conclusions: RBD can be comorbid with WD. RWA is commonly present in WD, both in the presence or absence of clinical RBD. A causal connection is possible, though retrospective determination of RBD onset and the low number of patients do not allow a definitive conclusion at this point. However, screening for WD in idiopathic RBD is available at low cost and is recommended. Early-stage copper chelation therapy provides a highly effective treatment to prevent further WD manifestations and might also control the comorbid RBD.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalSleep Medicine
StatePublished - Jun 10 2015

Bibliographical note

Funding Information:
The authors would like to acknowledge the support of the São Paulo Research Foundation (FAPESP, Fundação de Amparo à Pesquisa do Estado de São Paulo), grant 2012/05403-3 . The sponsor had no influence on the conduct of the research and/or the content of the article.

Publisher Copyright:
© 2015 Elsevier B.V.


  • Movement disorders
  • Parasomnias
  • Parkinsonian syndromes
  • Rapid eye movement sleep behavior disorder
  • Sleep disorders
  • Wilson's disease


Dive into the research topics of 'Wilson's disease with and without rapid eye movement sleep behavior disorder compared to healthy matched controls'. Together they form a unique fingerprint.

Cite this