Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents

Beth K. Thielen, Aaron M. T. Barnes, Arick P. Sabin, Becky Huebner, Susan Nelson, Elizabeth Wesenberg, Glen T. Hansen

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The Mucorales fungi—formerly classified as the zygomycetes—are environmentally ubiquitous fungi, but generally rare causes of clinical infections. In the immunocompromised host, however, they can cause invasive, rapidly spreading infections that confer a high risk of morbidity and mortality, often despite surgical and antifungal therapy. Patients with extensive burn injuries are particularly susceptible to skin and soft-tissue infections with these organisms. Here, we present a case of Lichtheimia infection in a patient with extensive full-thickness burns that required significant and repeated surgical debridement successfully treated with isavuconazole and adjunctive topical amphotericin B washes. We also review the available literature on contemporary antifungal treatment for Lichtheimia species and related Mucorales fungi.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalMycopathologia
DOIs
StatePublished - Jul 2018

Bibliographical note

Publisher Copyright:
© 2018 Springer Nature B.V.

Keywords

  • Absidia
  • Burn
  • Isavuconazole
  • Lichtheimia
  • Mucorales

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