Why methylene blue have to be always present in the stocking of emergency antidotes

Caroline F Baldo; Luiza M. Silva; Livia Arcêncio; Agnes A.S. Albuquerque; Andrea C. Celotto; Anibal Basile-Filho; Paulo R.B. Evora

doi:10.2174/1389450119666180403100410

Why methylene blue have to be always present in the stocking of emergency antidotes

Caroline F Baldo, Luiza M. Silva, Livia Arcêncio, Agnes A.S. Albuquerque, Andrea C. Celotto, Anibal Basile-Filho, Paulo R.B. Evora

Veterinary Clinical Sciences

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.

Original language	English (US)
Pages (from-to)	1550-1559
Number of pages	10
Journal	Current Drug Targets
Volume	19
Issue number	13
DOIs	https://doi.org/10.2174/1389450119666180403100410
State	Published - 2018

Bibliographical note

Funding Information:
This study was supported in part by CNPq, FAPESP and FAEPA.

Publisher Copyright:
© 2018 Bentham Science Publishers.

Keywords

Anaphylaxis
CGMP
Circulatory shock
Methylene blue
Neuroprotection
Nitric oxide
Poisoning

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10.2174/1389450119666180403100410

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title = "Why methylene blue have to be always present in the stocking of emergency antidotes",

abstract = "Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.",

keywords = "Anaphylaxis, CGMP, Circulatory shock, Methylene blue, Neuroprotection, Nitric oxide, Poisoning",

author = "Baldo, {Caroline F} and Silva, {Luiza M.} and Livia Arc{\^e}ncio and Albuquerque, {Agnes A.S.} and Celotto, {Andrea C.} and Anibal Basile-Filho and Evora, {Paulo R.B.}",

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doi = "10.2174/1389450119666180403100410",

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AU - Baldo, Caroline F

AU - Silva, Luiza M.

AU - Arcêncio, Livia

AU - Albuquerque, Agnes A.S.

AU - Celotto, Andrea C.

AU - Basile-Filho, Anibal

AU - Evora, Paulo R.B.

PY - 2018

Y1 - 2018

N2 - Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.

AB - Evidence-based review of the existing literature ultimately recommends stocking of Methylene Blue (MB) as an emergency antidote in the United States. The same is reported around the world in Japan, Greece, Italy and Canada. The observation that MB is always present as the main antidote required in emergency and critical care units calls for a revisit on its effects on the NO/cGMP system to reemphasize its multisystem actions. Therefore, the present review aimed to display the role of MB in emergency units, concerning: 1) Polytrauma and circulatory shock; 2) Neuroprotection, 3) Anaphylaxis and, 4) Overdose and poisoning.

KW - Anaphylaxis

KW - CGMP

KW - Circulatory shock

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KW - Neuroprotection

KW - Nitric oxide

KW - Poisoning

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Why methylene blue have to be always present in the stocking of emergency antidotes

Abstract

Bibliographical note

Keywords

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