Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?

Marjet Elemans, Nafisa-Katrin Seich Al Basatena, Nichole R Klatt, Christos Gkekas, Guido Silvestri, Becca Asquith

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.

Original languageEnglish (US)
Pages (from-to)e1002200
JournalPLoS computational biology
Volume7
Issue number9
DOIs
StatePublished - Sep 2011

Keywords

  • Animals
  • CD8-Positive T-Lymphocytes/cytology
  • Cell Survival
  • Computational Biology/methods
  • Lymphocyte Depletion
  • Macaca
  • Models, Theoretical
  • Simian Acquired Immunodeficiency Syndrome/virology
  • Simian Immunodeficiency Virus/metabolism
  • Viral Load
  • Viremia/immunology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't

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