Why do tubulin gene families lack diversity in flagellate/ciliate protists?

Carolyn D. Silflow

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Considerable amino acid sequence diversity is found among tubulin isotypes encoded by tubulin gene families in animal, higher plant, and fungal systems. In contrast, relatively little diversity is found among the isotypes produced by the gene families in a number of flagellate or ciliate protists. It is possible that proper assembly of the axoneme requires a homogeneous pool of tubulin subunits and that the axoneme thus provides a stringent selection against amino acid replacement substitutions among tubulin genes in these systems.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
Issue number1-3
StatePublished - Feb 1 1991


  • Axonemes
  • Microtubules
  • Tubulin genes
  • Tubulin isotypes


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