Why do cells need an assembly machine for RNA-protein complexes?

Jeongsik Yong, Lili Wan, Gideon Dreyfuss

Research output: Contribution to journalReview articlepeer-review

149 Scopus citations


Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The snRNP biogenesis pathway is complex, involving nuclear export of snRNA, Sm-core assembly in the cytoplasm and re-import of the mature snRNP. Although in vitro Sm cores assemble readily on uridine-rich RNAs, the assembly in cells is carried out by the survival of motor neurons (SMN) complex. The SMN complex stringently scrutinizes RNAs for specific features that define them as snRNAs and identifies the RNA-binding Sm proteins. We discuss how this surveillance capacity of the SMN complex might ensure assembly of Sm cores only on the correct RNAs and prevent illicit, potentially deleterious assembly of Sm cores on random RNAs.

Original languageEnglish (US)
Pages (from-to)226-232
Number of pages7
JournalTrends in Cell Biology
Issue number5
StatePublished - May 2004

Bibliographical note

Funding Information:
We thank the members of our laboratory, especially Amelie Gubitz and Daniel Battle, for helpful discussions and comments on this manuscript. The work in our laboratory reported here was supported by the Association Française Contre les Myopathies and by a grant from the NIH. G.D. is an Investigator of the Howard Hughes Medical Institute.


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