Why CD8+ T Cells Need Diversity When Growing Up

Research output: Contribution to journalShort survey

10 Citations (Scopus)

Abstract

A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that β5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.

Original languageEnglish (US)
Pages (from-to)5-6
Number of pages2
JournalImmunity
Volume32
Issue number1
DOIs
StatePublished - Jan 29 2010

Fingerprint

Proteasome Endopeptidase Complex
Thymus Gland
Immunity
Epithelial Cells
T-Lymphocytes
Peptides

Cite this

Why CD8+ T Cells Need Diversity When Growing Up. / Hogquist, Kristin A; Xing, Yan.

In: Immunity, Vol. 32, No. 1, 29.01.2010, p. 5-6.

Research output: Contribution to journalShort survey

@article{5128ae11ecba4151a6188b49981181c6,
title = "Why CD8+ T Cells Need Diversity When Growing Up",
abstract = "A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that β5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.",
author = "Hogquist, {Kristin A} and Yan Xing",
year = "2010",
month = "1",
day = "29",
doi = "10.1016/j.immuni.2010.01.005",
language = "English (US)",
volume = "32",
pages = "5--6",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Why CD8+ T Cells Need Diversity When Growing Up

AU - Hogquist, Kristin A

AU - Xing, Yan

PY - 2010/1/29

Y1 - 2010/1/29

N2 - A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that β5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.

AB - A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that β5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.

UR - http://www.scopus.com/inward/record.url?scp=74549185929&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74549185929&partnerID=8YFLogxK

U2 - 10.1016/j.immuni.2010.01.005

DO - 10.1016/j.immuni.2010.01.005

M3 - Short survey

C2 - 20152164

AN - SCOPUS:74549185929

VL - 32

SP - 5

EP - 6

JO - Immunity

JF - Immunity

SN - 1074-7613

IS - 1

ER -