Why CD8+ T Cells Need Diversity When Growing Up

Kristin A. Hogquist; Yan Xing

doi:10.1016/j.immuni.2010.01.005

Why CD8⁺ T Cells Need Diversity When Growing Up

Kristin A. Hogquist, Yan Xing

Laboratory Medicine and Pathology

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8⁺ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that β5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.

Original language	English (US)
Pages (from-to)	5-6
Number of pages	2
Journal	Immunity
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2010.01.005
State	Published - Jan 29 2010

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10.1016/j.immuni.2010.01.005

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title = "Why CD8+ T Cells Need Diversity When Growing Up",

abstract = "A thymus-specific subunit of the proteasome, β5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that β5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.",

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