Whole-cell screen of fragment library identifies gut microbiota metabolite indole propionic acid as antitubercular

Keyphrases

• Antitubercular 100%
• Whole Cell 100%
• Molecular Mass 100%
• Fragment Library 100%
• Gut Metabolites 100%
• 3-indolepropionic Acid 100%
• Pyrazinamide 66%
• Mycobacterium Tuberculosis (M. tb) 33%
• Drug Discovery 33%
• Mouse Model 33%
• Gut Microbiota 33%
• Pharmacokinetic Properties 33%
• Bacterial Load 33%
• Spleen 33%
• Growth Inhibition 33%
• Dose Effect 33%
• Antitubercular Activity 33%
• Latent Tuberculosis Infection 33%
• Indol 33%
• Antimycobacterial Activity 33%
• Anti-tuberculosis Drugs 33%
• Whole Cell Activity 33%
• Maybridge 33%
• Drug-like 33%
• Propiolic Acids 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Intestine Flora 100%
• Indolepropionic Acid 100%
• Pyrazinamide 100%
• Mouse 50%
• Drug Discovery 50%
• Mouse Model 50%
• Antitubercular Activity 50%
• Pharmacokinetics 50%
• Tuberculosis 50%
• Tuberculostatic Agent 50%
• Propionic Acid 50%
• Indole 50%
• Antimycobacterial Agent 50%
• Mycobacterium Tuberculosis 50%