Whole-Body Distribution of Leukemia and Functional Total Marrow Irradiation Based on FLT-PET and Dual-Energy CT

Taiki Magome, Jerry Froelich, Shernan G. Holtan, Yutaka Takahashi, Michael R. Verneris, Keenan Brown, Kathryn Dusenbery, Jeffrey Wong, Susanta K. Hui

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


This report describes a multimodal whole-body 3′-deoxy-3′[(18)F]-fluorothymidine positron emission tomography (FLT-PET) and dual-energy computed tomography (DECT) method to identify leukemia distribution within the bone marrow environment (BME) and to develop disease- and/or BME-specific radiation strategies. A control participant and a newly diagnosed patient with acute myeloid leukemia prior to induction chemotherapy were scanned with FLT-PET and DECT. The red marrow (RM) and yellow marrow (YM) of the BME were segmented from DECT using a basis material decomposition method. Functional total marrow irradiation (fTMI) treatment planning simulations were performed combining FLT-PET and DECT imaging to differentially target irradiation to the leukemia niche and the rest of the skeleton. Leukemia colonized both RM and YM regions, adheres to the cortical bone in the spine, and has enhanced activity in the proximal/distal femur, suggesting a potential association of leukemia with the BME. The planning target volume was reduced significantly in fTMI compared with conventional TMI. The dose to active disease (standardized uptake value >4) was increased by 2-fold, while maintaining doses to critical organs similar to those in conventional TMI. In conclusion, a hybrid system of functional–anatomical–physiological imaging can identify the spatial distribution of leukemia and will be useful to both help understand the leukemia niche and develop targeted radiation strategies.

Original languageEnglish (US)
JournalMolecular imaging
StatePublished - Sep 18 2017

Bibliographical note

Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was partly supported by various funders: National Institutes of Health grant 1R01CA154491-01, Grant-in-Aid (University of Minnesota), the Japan Society for the Promotion of Science (JSPS) Core-to-Core Program (No. 23003), Grant-in-Aid for JSPS Fellow (13J02944), and Grant-in-Aid for Young Scientists (B) (26860397).

Publisher Copyright:
© The Author(s) 2017.


  • dual-energy CT
  • functional total marrow irradiation
  • leukemia
  • red marrow
  • yellow marrow


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