Whole-body analysis of T cell responses

R. Lee Reinhardt, Marc K. Jenkins

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


In vivo methods to detect antigen-specific T cell responses at the single-cell level have greatly increased our knowledge of how the immune system works. However, most of these approaches have been confined to analysis of lymphoid tissues. Recently, the development of imaging techniques capable of simultaneously monitoring all the tissues of the body has led to the realization that antigen-experienced T cells reside in non-lymphoid tissues and may play a vital role in protecting the host against pathogens. Therefore, single-cell imaging at the level of the whole organism is needed to fully understand the dynamics of protective immunity.

Original languageEnglish (US)
Pages (from-to)366-371
Number of pages6
JournalCurrent Opinion in Immunology
Issue number4
StatePublished - Jun 2003

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