Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder

Elizabeth Aaron; Alicia Montgomery; Xinguo Ren; Stephen Guter; George Anderson; Ana M.D. Carneiro; Suma Jacob; Matthew Mosconi; Ghanshyam N. Pandey; Edwin Cook; Jeremy Veenstra-VanderWeele

doi:10.1007/s10803-019-03989-z

Whole Blood Serotonin Levels and Platelet 5-HT_2A Binding in Autism Spectrum Disorder

Elizabeth Aaron
, Alicia Montgomery
, Xinguo Ren
, Stephen Guter
, George Anderson
, Ana M.D. Carneiro
, Suma Jacob
, Matthew Mosconi
, Ghanshyam N. Pandey
, Edwin Cook
, Jeremy Veenstra-VanderWeele

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT_2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT_2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT_2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT_2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT_2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

Original language	English (US)
Pages (from-to)	2417-2425
Number of pages	9
Journal	Journal of Autism and Developmental Disorders
Volume	49
Issue number	6
DOIs	https://doi.org/10.1007/s10803-019-03989-z
State	Published - Jun 2019

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2019.

Keywords

Autism spectrum disorder
Biomarker
Hyperserotonemia
Receptor
Serotonin

Publisher link

10.1007/s10803-019-03989-z

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Cite this

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title = "Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder",

abstract = "Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.",

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author = "Elizabeth Aaron and Alicia Montgomery and Xinguo Ren and Stephen Guter and George Anderson and Carneiro, \{Ana M.D.\} and Suma Jacob and Matthew Mosconi and Pandey, \{Ghanshyam N.\} and Edwin Cook and Jeremy Veenstra-VanderWeele",

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AU - Aaron, Elizabeth

AU - Montgomery, Alicia

AU - Ren, Xinguo

AU - Guter, Stephen

AU - Anderson, George

AU - Carneiro, Ana M.D.

AU - Jacob, Suma

AU - Mosconi, Matthew

AU - Pandey, Ghanshyam N.

AU - Cook, Edwin

AU - Veenstra-VanderWeele, Jeremy

N1 - Publisher Copyright: © Springer Science+Business Media, LLC, part of Springer Nature 2019.

PY - 2019/6

Y1 - 2019/6

N2 - Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

AB - Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

KW - Autism spectrum disorder

KW - Biomarker

KW - Hyperserotonemia

KW - Receptor

KW - Serotonin

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