Whole Blood Serotonin Levels and Platelet 5-HT2A Binding in Autism Spectrum Disorder

Elizabeth Aaron, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M.D. Carneiro, Suma Jacob, Matthew Mosconi, Ghanshyam N. Pandey, Edwin Cook, Jeremy Veenstra-VanderWeele

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

Original languageEnglish (US)
Pages (from-to)2417-2425
Number of pages9
JournalJournal of Autism and Developmental Disorders
Issue number6
StatePublished - Jun 2019

Bibliographical note

Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2019.


  • Autism spectrum disorder
  • Biomarker
  • Hyperserotonemia
  • Receptor
  • Serotonin


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