Whole Blood Serotonin Levels and Platelet 5-HT 2A Binding in Autism Spectrum Disorder

Elizabeth Aaron, Alicia Montgomery, Xinguo Ren, Stephen Guter, George Anderson, Ana M.D. Carneiro, Suma Jacob, Matthew Mosconi, Ghanshyam N. Pandey, Edwin Cook, Jeremy Veenstra-VanderWeele

Research output: Contribution to journalArticle

Abstract

Elevated whole blood serotonin (WB5-HT) is a well-replicated biomarker in autism spectrum disorder (ASD). Decreased platelet serotonin receptor 5-HT 2A binding has been reported in ASD. WB5-HT levels and platelet 5-HT 2A specific binding were obtained from 110 individuals with ASD and 18 controls. Individuals with ASD had significantly higher WB5-HT levels than controls. There was no difference in the platelet 5-HT 2A specific binding between groups. Multiple regression analyses revealed that platelet 5-HT 2A binding significantly predicted WB5-HT in the control sample but not in the ASD sample. These results indicate that the relationship between WB5-HT and platelet 5-HT 2A binding differs depending on ASD diagnosis, suggesting differences in platelet 5-HT system regulation in ASD.

Original languageEnglish (US)
JournalJournal of Autism and Developmental Disorders
DOIs
StatePublished - Jan 1 2019

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Keywords

  • Autism spectrum disorder
  • Biomarker
  • Hyperserotonemia
  • Receptor
  • Serotonin

Cite this

Aaron, E., Montgomery, A., Ren, X., Guter, S., Anderson, G., Carneiro, A. M. D., Jacob, S., Mosconi, M., Pandey, G. N., Cook, E., & Veenstra-VanderWeele, J. (2019). Whole Blood Serotonin Levels and Platelet 5-HT 2A Binding in Autism Spectrum Disorder Journal of Autism and Developmental Disorders. https://doi.org/10.1007/s10803-019-03989-z