White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study

Igor Nestrasil, Alena Svatkova, Kyle D. Rudser, Ravishankar Chityala, Amy Wakumoto, Bryon A. Mueller, Petr Bednařík, Paul Tuite, Xiang Wu, Khalaf Bushara

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background: An evolving pathophysiological concept of essential tremor (ET) points to diffuse brain network involvement, which emphasizes the need to investigate white matter (WM) changes associated with motor symptoms of ET. Objectives: To investigate ET-related WM changes and WM correlates of tremor severity using tremor clinical rating scales and accelerometry. Methods: Tract-based spatial statistics (TBSS) approach was utilized to compare 3 Tesla diffusion tensor imaging (DTI) data from 12 ET patients and 10 age- and gender-matched healthy individuals. Clinical scales, tremor frequency and amplitude as measured by accelerometry were correlated with DTI data. Results: ET patients demonstrated mean (MD) and radial diffusivity (RD) abnormalities in tracts involved in primary and associative motor functions such as bilateral corticospinal tracts, the superior longitudinal fascicles, and the corpus callosum but also in nonmotor regions including the inferior fronto-occipital and longitudinal fascicles, cingulum bundles, anterior thalamic radiations, and uncinate fascicles. A combined tremor frequency and amplitude score correlated with RD and MD in extensive WM areas, which partially overlapped the regions that were associated with tremor frequency. No significant relationship was found between DTI measures and clinical rating scales scores. Conclusions: The results show that ET-related diffusion WM changes and their correlates with tremor severity are preferentially located in the primary and associative motor areas. In contrast, a relationship between WM was not detected with clinical rating scales. Accelerometry parameters may, therefore, serve as a potentially useful clinical measures that relate to WM deficits in ET.

Original languageEnglish (US)
Article numbere01039
JournalBrain and Behavior
Volume8
Issue number8
DOIs
StatePublished - Aug 2018

Bibliographical note

Funding Information:
We thank Diane Hutter, RN for her help with patient's recruitment. We are grateful to the subjects who participated in this study as well as the Center for Neurobehavioral Development (CNBD), the Center for Magnetic Resonance Research (CMRR), and the Minnesota Supercomputer Center (MSI) for the provision of infrastructure for this research. The study was supported by grants from the International Tremor Foundation (to KB), The Department of Veterans Affairs (to KB), University of Minnesota Foundation (to PT), National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 and by the project ?CEITEC 2020 (LQ1601)? from the Ministry of Education, Youth and Sports of the Czech Republic (to AS).

Funding Information:
National Center for Advancing Translational Sciences of the National Institutes of Health, Grant/Award Number: UL1TR000114; The Department of Veterans Affairs; Ministry of Education, Youth and Sports of the Czech Republic; International Tremor Foundation; University of Minnesota Foundation

Funding Information:
We thank Diane Hutter, RN for her help with patient’s recruitment. We are grateful to the subjects who participated in this study as well as the Center for Neurobehavioral Development (CNBD), the Center for Magnetic Resonance Research (CMRR), and the Minnesota Supercomputer Center (MSI) for the provision of infrastructure for this research. The study was supported by grants from the International Tremor Foundation (to KB), The Department of Veterans Affairs (to KB), University of Minnesota Foundation (to PT), National Center for Advancing Translational Sciences of the National Institutes of Health Award Number UL1TR000114 and by the project “CEITEC 2020 (LQ1601)” from the Ministry of Education, Youth and Sports of the Czech Republic (to AS).

Publisher Copyright:
© 2018 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.

Keywords

  • Guillain-Mollaret triangle
  • TremScore
  • diffusion tensor imaging
  • essential tremor
  • radial diffusivity
  • tremor network

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