White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression

Christopher F. Murphy, Faith M. Gunning-Dixon, Matthew J. Hoptman, Kelvin O. Lim, Babak Ardekani, Jessica K. Shields, Jan Hrabe, Dora Kanellopoulos, Bindu R. Shanmugham, George S. Alexopoulos

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

Background: This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders. Method: Fifty-one elders with major depression participated in a 12-week escitalopram trial. Diffusion tensor imaging was used to determine fractional anisotropy (FA) in white matter regions. Executive function (response inhibition) was assessed with the Stroop task. Voxelwise correlational analysis was used to examine the relationship between Stroop performance and fractional anisotropy. Results: Significant associations between FA and Stroop color word interference were evident in multiple frontostriatal-limbic regions, including white matter lateral to the anterior and posterior cingulate cortex and white matter in prefrontal, insular, and parahippocampal regions. Conclusions: These findings suggest that microstructural white matter abnormalities of frontostriatal-limbic networks are associated with executive dysfunction of late-life depression. This observation provides the rationale for examination of specific frontostriatal-limbic pathways in the pathophysiology of geriatric depression.

Original languageEnglish (US)
Pages (from-to)1007-1010
Number of pages4
JournalBiological Psychiatry
Volume61
Issue number8
DOIs
StatePublished - Apr 15 2007

Keywords

  • DTI
  • Depression
  • MRI
  • Stroop
  • executive function
  • geriatric

Fingerprint Dive into the research topics of 'White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression'. Together they form a unique fingerprint.

  • Cite this

    Murphy, C. F., Gunning-Dixon, F. M., Hoptman, M. J., Lim, K. O., Ardekani, B., Shields, J. K., Hrabe, J., Kanellopoulos, D., Shanmugham, B. R., & Alexopoulos, G. S. (2007). White-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression. Biological Psychiatry, 61(8), 1007-1010. https://doi.org/10.1016/j.biopsych.2006.07.028