White matter and neurocognitive changes in adults with chronic traumatic brain injury

Mary R.T. Kennedy, Jeffrey R. Wozniak, Ryan L. Muetzel, Bryon A. Mueller, Hsin Huei Chiou, Kari Pantekoek, Kelvin O. Lim

Research output: Contribution to journalArticlepeer-review

71 Scopus citations


Diffusion tensor imaging was used to investigate white matter (WM) integrity in adults with traumatic brain injury (TBI) and healthy adults as controls. Adults with TBI had sustained severe vehicular injuries on the average of 7 years earlier. A multivariate analysis of covariance with verbal IQ as the covariate revealed that adults with TBI had lower fractional anisotropy and higher mean diffusivity than controls, specifically in the three regions of interest (ROIs), the centrum semiovale (CS), the superior frontal (SPF), and the inferior frontal (INF). Adults with TBI averaged in the normal range in motor speed and two of three executive functions and were below average in delayed verbal recall and inhibition, whereas controls were above average. Time since injury, but not age, was associated with WM changes in the SPF ROI, whereas age, but not time since injury, was associated with WM changes in the INF ROI, suggesting that the effects of WM on time since injury may interact with age. To understand the utility of WM changes in chronic recovery, larger sample sizes are needed to investigate associations between cognition and WM integrity of severely injured individuals who have substantial cognitive impairment compared to severely injured individuals with little cognitive impairment.

Original languageEnglish (US)
Pages (from-to)130-136
Number of pages7
JournalJournal of the International Neuropsychological Society
Issue number1
StatePublished - 2009


  • Anisotropy
  • Brain injury
  • Cognition
  • Diffusion tensor imaging
  • Executive functions


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