White matter abnormalities in skin picking disorder: A diffusion tensor imaging study

Jon E. Grant, Brian L. Odlaug, Adam Hampshire, Liana R.N. Schreiber, Samuel R. Chamberlain

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

Skin picking disorder (SPD) is characterized by the repetitive and compulsive picking of skin, resulting in tissue damage. Neurocognitive findings in SPD implicate difficulty with response inhibition (suppression of pre-potent motor responses). This function is dependent on the integrity of the right frontal gyrus and the anterior cingulate cortices, and white-matter tracts connecting such neural nodes. It was hypothesized that SPD would be associated with reduced fractional anisotropy in regions implicated in top-down response suppression, particularly white-matter tracts in proximity of the bilateral anterior cingulate and right frontal (especially orbitofrontal and inferior frontal) cortices. 13-subjects meeting proposed SPD criteria for DSM-5 free from other current psychiatric comorbidities, anD12 healthy comparison subjects underwent MRI with a 3-T system. Between-group comparisons of imaging data underwent voxelwise analysis with permutation modeling and cluster correction. Fractional anisotropy (measured using diffusion tensor imaging) was the primary outcome measure. Subjects with SPD exhibited significantly reduced fractional anisotropy in tracts distributed bilaterally, which included the anterior cingulate cortices. Fractional anisotropy did not correlate significantly with SPD disease severity, or depressive or anxiety scores. These findings implicate disorganization of white-matter tracts involved in motor generation and suppression in the pathophysiology of SPD, findings remarkably similar to those previously reported in trichotillomania. This study adds considerable support to the notion that-in addition to the phenomenological and comorbid overlap between SPD and trichotillomania-these disorders likely share overlapping neurobiology.

Original languageEnglish (US)
Pages (from-to)763-769
Number of pages7
JournalNeuropsychopharmacology
Volume38
Issue number5
DOIs
StatePublished - Apr 2013
Externally publishedYes

Bibliographical note

Funding Information:
Dr Grant has received research grant support from NIDA, NCRG, Psyadon Pharmaceuticals, Forest Pharmaceuticals, Transcept Pharmaceuticals, and the University of South Florida. He has also received royalties from American Psychiatric Publishing Inc, Oxford University Press, Norton, and McGraw Hill Publishers. Mr Odlaug has received research grants from the Trichotillomania Learning Center, has consulted for Lundbeck Pharmaceuticals, and reports having received honoraria and royalties from Oxford University Press. Dr Chamberlain has consulted for Cambridge Cognition, P1Vital, Shire, and Lilly. The remaining authors declare no conflict of interest.

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • diffusion tensor
  • imaging
  • skin picking
  • white matter

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