TY - JOUR
T1 - White fat progenitor cells reside in the adipose vasculature
AU - Tang, Wei
AU - Zeve, Daniel
AU - Suh, Jae Myoung
AU - Bosnakovski, Darko
AU - Kyba, Michael
AU - Hammer, Robert E.
AU - Tallquist, Michelle D.
AU - Graff, Jonathan M.
PY - 2008/10/24
Y1 - 2008/10/24
N2 - White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.
AB - White adipose (fat) tissues regulate metabolism, reproduction, and life span. Adipocytes form throughout life, with the most marked expansion of the lineage occurring during the postnatal period. Adipocytes develop in coordination with the vasculature, but the identity and location of white adipocyte progenitor cells in vivo are unknown. We used genetically marked mice to isolate proliferating and renewing adipogenic progenitors. We found that most adipocytes descend from a pool of these proliferating progenitors that are already committed, either prenatally or early in postnatal life. These progenitors reside in the mural cell compartment of the adipose vasculature, but not in the vasculature of other tissues. Thus, the adipose vasculature appears to function as a progenitor niche and may provide signals for adipocyte development.
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U2 - 10.1126/science.1156232
DO - 10.1126/science.1156232
M3 - Article
C2 - 18801968
AN - SCOPUS:53549130485
SN - 0036-8075
VL - 322
SP - 583
EP - 586
JO - Science
JF - Science
IS - 5901
ER -