Abstract
Current evidence suggests that delta oscillations (0.5-4â ‰Hz) in the brain are generated by intrinsic network mechanisms involving cortical and thalamic circuits. Here we report that delta band oscillation in spike and local field potential (LFP) activity in the whisker barrel cortex of awake mice is phase locked to respiration. Furthermore, LFP oscillations in the gamma frequency band (30-80â ‰Hz) are amplitude modulated in phase with the respiratory rhythm. Removal of the olfactory bulb eliminates respiration-locked delta oscillations and delta-gamma phase-amplitude coupling. Our findings thus suggest respiration-locked olfactory bulb activity as a main driving force behind delta oscillations and gamma power modulation in the whisker barrel cortex in the awake state.
| Original language | English (US) |
|---|---|
| Article number | 3572 |
| Journal | Nature communications |
| Volume | 5 |
| DOIs | |
| State | Published - Apr 1 2014 |
| Externally published | Yes |
Bibliographical note
Funding Information:We thank Shuhua Qi for techncal assistance and Michael Nguyen for custom-machined parts. We also thank S. du Lac, D. Linden, M. Ennis and H. Kita for valuable suggestions and comments on earlier versions on this manuscript. This work was supported by grants NS060887, NS067201 from the National Institute of Health to D.H.H. and by the Helmholtz Alliance on Systems Biology, and Helmholtz Portfolio Supercomputing and Modeling for the Human Brain (SMHB) and BrainScales (EU Grant 269912) to S.G. Additional intramural support to D.H.H. was obtained from the UTHSC College of Medicine.