When ligand becomes receptor — Tolerance via B7 signaling on DCs

Erik B. Finger, Jeffrey A. Bluestone

Research output: Contribution to journalComment/debate

93 Citations (Scopus)

Abstract

In summary, Grohmann et al. have described a pathway of tolerance induction that focuses on the role of the APC rather than the T cell as the principle discriminator of function. Although it is likely that this pathway is only one of several alternative modes of tolerance, it has potentially great therapeutic implications for transplantation, autoimmunity and tumor immunology.

Original languageEnglish (US)
Pages (from-to)1056-1057
Number of pages2
JournalNature Immunology
Volume3
Issue number11
DOIs
StatePublished - Jan 1 2002

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Allergy and Immunology
Autoimmunity
Transplantation
Ligands
T-Lymphocytes
Neoplasms
Therapeutics

Cite this

When ligand becomes receptor — Tolerance via B7 signaling on DCs. / Finger, Erik B.; Bluestone, Jeffrey A.

In: Nature Immunology, Vol. 3, No. 11, 01.01.2002, p. 1056-1057.

Research output: Contribution to journalComment/debate

Finger, Erik B. ; Bluestone, Jeffrey A. / When ligand becomes receptor — Tolerance via B7 signaling on DCs. In: Nature Immunology. 2002 ; Vol. 3, No. 11. pp. 1056-1057.
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