What we know: Findings that every theory of Schizophrenia should explain

Angus W. MacDonald, S. Charles Schulz

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


The article summarizes the process used to distill schizophrenia science into 22 facts. These facts consist of 6 basic facts, 3 etiological facts, 6 pharmacological and treatment facts, 5 pathology facts, and 2 behavioral facts that were critically reviewed by the scholarly community through a special initiative in cooperation with the Schizophrenia Research Forum. A subset of 10 of these facts was selected to form a common set of findings to be explained from the different theoretical perspectives included in this special section of Schizophrenia Bulletin. The rationale for this exercise is to distinguish more precisely the areas of agreement and disagreement between theories of schizophrenia and to highlight where more thought and data can make the greatest impact for understanding this disease.

Original languageEnglish (US)
Pages (from-to)493-508
Number of pages16
JournalSchizophrenia bulletin
Issue number3
StatePublished - May 2009


  • Meta-analysis
  • Review
  • Schizophrenia
  • Theory


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