What mechanisms contribute to the strength loss that occurs during and in the recovery from skeletal muscle injury?

Gordon L. Warren, Christopher P. Ingalls, Dawn A. Lowe, R. B. Armstrong

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

In the workplace or on the athletic field, muscle strength can be decreased by 50% or more following performance of a relatively few high-force, eccentric contractions. The strength loss can be prolonged, taking a month or more for complete recovery. It is important to understand the cause(s) of the strength loss so we can develop means of preventing or attenuating this loss. The cellular-level mechanisms explaining the loss of strength following contraction-induced muscle injury remain controversial. The traditional thought is that initial strength loss is due solely to damage to force-bearing structures within the muscle, as evidenced by histopathology. In addition, inflammation in the days following injury is commonly thought to exacerbate the strength loss. We present data to the contrary. Recent data show that most of the early strength loss results from a failure of excitation-contraction coupling processes and that a slow loss of contractile protein in the days following injury prolongs the time for recovery. J Orthop Sports Phys Ther 2002;32:58-64.

Original languageEnglish (US)
Pages (from-to)58-64
Number of pages7
JournalJournal of Orthopaedic and Sports Physical Therapy
Volume32
Issue number2
DOIs
StatePublished - Jan 1 2002

Fingerprint

Skeletal Muscle
Sports
Wounds and Injuries
Contractile Proteins
Excitation Contraction Coupling
Muscle Strength
Muscle Contraction
Workplace
Inflammation
Muscles

Keywords

  • Calcium
  • Eccentric
  • Excitation-contraction coupling
  • Strength

Cite this

What mechanisms contribute to the strength loss that occurs during and in the recovery from skeletal muscle injury? / Warren, Gordon L.; Ingalls, Christopher P.; Lowe, Dawn A.; Armstrong, R. B.

In: Journal of Orthopaedic and Sports Physical Therapy, Vol. 32, No. 2, 01.01.2002, p. 58-64.

Research output: Contribution to journalReview article

@article{0dbc2ae5e4b74fd6a456cadfcde00587,
title = "What mechanisms contribute to the strength loss that occurs during and in the recovery from skeletal muscle injury?",
abstract = "In the workplace or on the athletic field, muscle strength can be decreased by 50{\%} or more following performance of a relatively few high-force, eccentric contractions. The strength loss can be prolonged, taking a month or more for complete recovery. It is important to understand the cause(s) of the strength loss so we can develop means of preventing or attenuating this loss. The cellular-level mechanisms explaining the loss of strength following contraction-induced muscle injury remain controversial. The traditional thought is that initial strength loss is due solely to damage to force-bearing structures within the muscle, as evidenced by histopathology. In addition, inflammation in the days following injury is commonly thought to exacerbate the strength loss. We present data to the contrary. Recent data show that most of the early strength loss results from a failure of excitation-contraction coupling processes and that a slow loss of contractile protein in the days following injury prolongs the time for recovery. J Orthop Sports Phys Ther 2002;32:58-64.",
keywords = "Calcium, Eccentric, Excitation-contraction coupling, Strength",
author = "Warren, {Gordon L.} and Ingalls, {Christopher P.} and Lowe, {Dawn A.} and Armstrong, {R. B.}",
year = "2002",
month = "1",
day = "1",
doi = "10.2519/jospt.2002.32.2.58",
language = "English (US)",
volume = "32",
pages = "58--64",
journal = "Journal of Orthopaedic and Sports Physical Therapy",
issn = "0190-6011",
publisher = "JOSPT",
number = "2",

}

TY - JOUR

T1 - What mechanisms contribute to the strength loss that occurs during and in the recovery from skeletal muscle injury?

AU - Warren, Gordon L.

AU - Ingalls, Christopher P.

AU - Lowe, Dawn A.

AU - Armstrong, R. B.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - In the workplace or on the athletic field, muscle strength can be decreased by 50% or more following performance of a relatively few high-force, eccentric contractions. The strength loss can be prolonged, taking a month or more for complete recovery. It is important to understand the cause(s) of the strength loss so we can develop means of preventing or attenuating this loss. The cellular-level mechanisms explaining the loss of strength following contraction-induced muscle injury remain controversial. The traditional thought is that initial strength loss is due solely to damage to force-bearing structures within the muscle, as evidenced by histopathology. In addition, inflammation in the days following injury is commonly thought to exacerbate the strength loss. We present data to the contrary. Recent data show that most of the early strength loss results from a failure of excitation-contraction coupling processes and that a slow loss of contractile protein in the days following injury prolongs the time for recovery. J Orthop Sports Phys Ther 2002;32:58-64.

AB - In the workplace or on the athletic field, muscle strength can be decreased by 50% or more following performance of a relatively few high-force, eccentric contractions. The strength loss can be prolonged, taking a month or more for complete recovery. It is important to understand the cause(s) of the strength loss so we can develop means of preventing or attenuating this loss. The cellular-level mechanisms explaining the loss of strength following contraction-induced muscle injury remain controversial. The traditional thought is that initial strength loss is due solely to damage to force-bearing structures within the muscle, as evidenced by histopathology. In addition, inflammation in the days following injury is commonly thought to exacerbate the strength loss. We present data to the contrary. Recent data show that most of the early strength loss results from a failure of excitation-contraction coupling processes and that a slow loss of contractile protein in the days following injury prolongs the time for recovery. J Orthop Sports Phys Ther 2002;32:58-64.

KW - Calcium

KW - Eccentric

KW - Excitation-contraction coupling

KW - Strength

UR - http://www.scopus.com/inward/record.url?scp=0036157572&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036157572&partnerID=8YFLogxK

U2 - 10.2519/jospt.2002.32.2.58

DO - 10.2519/jospt.2002.32.2.58

M3 - Review article

VL - 32

SP - 58

EP - 64

JO - Journal of Orthopaedic and Sports Physical Therapy

JF - Journal of Orthopaedic and Sports Physical Therapy

SN - 0190-6011

IS - 2

ER -