What Gesell wished, Hellbrügge accomplished: Chronomics of child development

Germaine G Cornelissen-Guillaume, Franz Halberg, Othild Schwartzkopff, George Katinas, Dana E Johnson, Kuniaki Otsuka, Yoshihiko Watanabe, Zhengrong Wang, Chaomin Wan, Federico Perfetto, Roberto Tarquini, Cristina Maggioni, Elena V. Syutkina, Anatoly Masalov, Jarmila Siegelova, Ziyan Zhao, R. B. Singh, R. K. Singh, Anatoly Delyukov, Yuri GorgoRina M. Zaslavskaya, Gennady D. Gubin, Denis G. Gubin, Yuji Kumagai, Keiko Uezono, Douglas Wilson, Andi Weydahl, Earl Bakken

Research output: Contribution to journalEditorialpeer-review

6 Scopus citations


The meeting here summarized was organized in behalf of Theodor Hellbrügge, the founder of social pediatrics, who started in the early 1950s what became chronobiology and chronomics. He and his school described the circadian rhythm in many biological functions, such as body temperature, blood pressure, heart rate, respiratory rate, peak expiratory flow, and the response of patients treated by corticosteroids and other drugs. Elsewhere, we reviewed the significance of chronobiology for human development and outline some tasks for further research and for prehabilitation. The recognition of invisible disease risks by physiological monitoring and the computer-aided resolution of time structures, chronomes, for this purpose and many others, basic and applied, is the task of pediatric chronomics, that complement chronobiology as genomics and proteomics complement genetics.

Original languageEnglish (US)
Pages (from-to)14-24
Number of pages11
JournalNeuroendocrinology Letters
Issue numberSUPPL. 1
StatePublished - 2003


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