Well-Differentiated Liposarcoma/Atypical Lipomatous Tumor of the Oral Cavity: Report of Three Cases and Review of the Literature

Evangelia Piperi, Konstantinos I. Tosios, Nikolaos G. Nikitakis, Vasileios F. Kyriakopoulos, Fotios Tzerbos, Ioannis G. Koutlas, Alexandra Sklavounou

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Atypical Lipomatous Tumor/Well Differentiated Liposarcoma (ALT/WDLS) is a soft tissue sarcoma of intermediate malignant behavior, most frequently affecting the retroperitoneum and lower extremities. Oral liposarcomas are very rare neoplasms, the most common histological subtype being ALT/WDLS. In this study, three additional cases of ALT/WDLS located on the tongue (2 cases) and the lower lip (1 case), respectively, are described. Analysis of the salient clinicopathologic features of 63 oral ALT/WDLS cases previously reported in the English language literature, as well as of the 3 cases presented in this study, indicates that the indolent biologic behavior of this tumor justifies its designation as a locally spreading malignant neoplasm, affording a rather conservative surgical approach.

Original languageEnglish (US)
Pages (from-to)354-363
Number of pages10
JournalHead and Neck Pathology
Volume6
Issue number3
DOIs
StatePublished - Sep 1 2012

Keywords

  • Atypical lipoma
  • Liposarcoma
  • Oral neoplasms
  • Soft tissue sarcoma

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