Weight change in the first 2 months of a lifestyle intervention predicts weight changes 8 years later

Objective Examine the relationship between 1- and 2-month weight loss (WL) and 8-year WL among participants enrolled in a lifestyle intervention. Methods 2,290 Look AHEAD participants (BMI: 35.65-±-5.93 kg/m²) with type 2 diabetes received an intensive behavioral WL intervention. Results 1- and 2-month WL were associated with yearly WL through Year 8 (P's-<-0.0001). At Month 1, participants losing 2-4% and >4% had 1.62 (95% CI: 1.32, 1.98) and 2.79 (95% CI: 2.21, 3.52) times higher odds of achieving ≥5% WL at Year 4 and 1.28 (95% CI: 1.05,1.58) and 1.77 (95% CI: 1.40, 2.24) times higher odds of achieving ≥5% WL at Year 8, compared to those losing <2% initially. At Month 2, 3-6% WL resulted in greater odds of achieving ≥5% WL at Year 4 (OR-=-1.85; CI: 1.48, 2.32), and >6% WL resulted in the greatest odds of achieving ≥5% WL at Year 4 (OR-=-3.85; CI: 3.05, 4.88) and Year 8 (OR-=-2.28; CI: 1.81, 2.89), compared to those losing <3%. Differences in adherence between WL categories were observed as early as Month 2. Conclusions 1- and 2-month WL was associated with 8-year WL. Future studies should examine whether alternative treatment strategies can be employed to improve treatment outcomes among those with low initial WL.