Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study

Look AHEAD Research Group

doi:10.1002/oby.22769

Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study

Look AHEAD Research Group

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

OBJECTIVE: This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.

METHODS: Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.

RESULTS: Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean (SE) of 1.2 (0.2) kg and 1.8 (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.

CONCLUSIONS: Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.

Original language	English (US)
Pages (from-to)	893-901
Number of pages	9
Journal	Obesity
Volume	28
Issue number	5
DOIs	https://doi.org/10.1002/oby.22769
State	Published - May 1 2020

Bibliographical note

Funding Information:
This research was funded by the NIH through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. Additional funding was provided by the National Heart, Lung, and Blood Institute, the National Institute of Nursing Research, the National Institute on Minority Health and Health Disparities, the NIH Office of Research on Women’s Health, and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the NIDDK. The Indian Health Service provided personnel, medical oversight, and use of facilities. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service or the other funding sources. Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066); the Harvard Clinical and Translational Science Center (RR025758‐04); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056) and the Clinical and Translational Research Center, funded by Clinical and Translational Science Award UL1 RR 024153 and NIH grant DK 046204; the US Department of Veterans Affairs Puget Sound Health Care System Medical Research Service; and the Frederic C. Bartter General Clinical Research Center (M01RR01346). The following organizations have committed to making major contributions to Look AHEAD: FedEx Corporation; Health Management Resources; LifeScan, Inc., a Johnson & Johnson Company; OPTIFAST of Nestle HealthCare Nutrition, Inc.; Hoffmann‐La Roche Inc.; Abbott Nutrition; and Slim‐Fast brand of Unilever, North America. AMC was supported, in part, by the National Institute of Nursing Research of the National Institutes of Health under Award Number K23NR017209.

Funding Information:
Look AHEAD data are available through the NIH/NIDDK Central Repository (https://repository.niddk.nih.gov/home/). These data sets include deidentified participant-level data. At this time, data are available beginning with the recruitment and randomization of participants (2001) through the end of the Look AHEAD intervention (2012) or for approximately 9 years of trial data on each participant. The study protocol, data collection forms, and data dictionaries are provided at this link. Requests for data are made through the NIDDK.

Publisher Copyright:
© 2020 The Obesity Society.

Keywords

Aged
Female
Humans
Life Style
Male
Middle Aged
Obesity/therapy
Weight Loss/physiology

PubMed: MeSH publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Randomized Controlled Trial
Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/oby.22769

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@article{bf7d19fb749e47f0919b17d3b415ba91,

title = "Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study",

abstract = "OBJECTIVE: This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.METHODS: Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.RESULTS: Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean (SE) of 1.2 (0.2) kg and 1.8 (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.CONCLUSIONS: Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.",

keywords = "Aged, Female, Humans, Life Style, Male, Middle Aged, Obesity/therapy, Weight Loss/physiology",

author = "{Look AHEAD Research Group} and Chao, {Ariana M.} and Wadden, {Thomas A.} and Berkowitz, {Robert I.} and George Blackburn and Paula Bolin and Clark, {Jeanne M.} and Mace Coday and Curtis, {Jeffrey M.} and Delahanty, {Linda M.} and Dutton, {Gareth R.} and Mary Evans and Ewing, {Linda J.} and Foreyt, {John P.} and Gay, {Linda J.} and Gregg, {Edward W.} and Hazuda, {Helen P.} and Hill, {James O.} and Horton, {Edward S.} and Houston, {Denise K.} and Jakicic, {John M.} and Jeffery, {Robert W.} and Johnson, {Karen C.} and Kahn, {Steven E.} and Knowler, {William C.} and Anne Kure and Michalski, {Katherine L.} and Montez, {Maria G.} and Neiberg, {Rebecca H.} and Jennifer Patricio and Anne Peters and Xavier Pi-Sunyer and Henry Pownall and David Reboussin and Bruce Redmon and Rejeski, {W. Jack} and Helmut Steinburg and Martha Walker and Williamson, {Donald A.} and Wing, {Rena R.} and Holly Wyatt and Yanovski, {Susan Z.} and Ping Zhang",

note = "Funding Information: This research was funded by the NIH through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. Additional funding was provided by the National Heart, Lung, and Blood Institute, the National Institute of Nursing Research, the National Institute on Minority Health and Health Disparities, the NIH Office of Research on Women{\textquoteright}s Health, and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the NIDDK. The Indian Health Service provided personnel, medical oversight, and use of facilities. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service or the other funding sources. Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066); the Harvard Clinical and Translational Science Center (RR025758‐04); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056) and the Clinical and Translational Research Center, funded by Clinical and Translational Science Award UL1 RR 024153 and NIH grant DK 046204; the US Department of Veterans Affairs Puget Sound Health Care System Medical Research Service; and the Frederic C. Bartter General Clinical Research Center (M01RR01346). The following organizations have committed to making major contributions to Look AHEAD: FedEx Corporation; Health Management Resources; LifeScan, Inc., a Johnson & Johnson Company; OPTIFAST of Nestle HealthCare Nutrition, Inc.; Hoffmann‐La Roche Inc.; Abbott Nutrition; and Slim‐Fast brand of Unilever, North America. AMC was supported, in part, by the National Institute of Nursing Research of the National Institutes of Health under Award Number K23NR017209. Funding Information: Look AHEAD data are available through the NIH/NIDDK Central Repository (https://repository.niddk.nih.gov/home/). These data sets include deidentified participant-level data. At this time, data are available beginning with the recruitment and randomization of participants (2001) through the end of the Look AHEAD intervention (2012) or for approximately 9 years of trial data on each participant. The study protocol, data collection forms, and data dictionaries are provided at this link. Requests for data are made through the NIDDK. Publisher Copyright: {\textcopyright} 2020 The Obesity Society.",

year = "2020",

month = may,

day = "1",

doi = "10.1002/oby.22769",

language = "English (US)",

volume = "28",

pages = "893--901",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "5",

}

TY - JOUR

T1 - Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study

AU - Look AHEAD Research Group

AU - Chao, Ariana M.

AU - Wadden, Thomas A.

AU - Berkowitz, Robert I.

AU - Blackburn, George

AU - Bolin, Paula

AU - Clark, Jeanne M.

AU - Coday, Mace

AU - Curtis, Jeffrey M.

AU - Delahanty, Linda M.

AU - Dutton, Gareth R.

AU - Evans, Mary

AU - Ewing, Linda J.

AU - Foreyt, John P.

AU - Gay, Linda J.

AU - Gregg, Edward W.

AU - Hazuda, Helen P.

AU - Hill, James O.

AU - Horton, Edward S.

AU - Houston, Denise K.

AU - Jakicic, John M.

AU - Jeffery, Robert W.

AU - Johnson, Karen C.

AU - Kahn, Steven E.

AU - Knowler, William C.

AU - Kure, Anne

AU - Michalski, Katherine L.

AU - Montez, Maria G.

AU - Neiberg, Rebecca H.

AU - Patricio, Jennifer

AU - Peters, Anne

AU - Pi-Sunyer, Xavier

AU - Pownall, Henry

AU - Reboussin, David

AU - Redmon, Bruce

AU - Rejeski, W. Jack

AU - Steinburg, Helmut

AU - Walker, Martha

AU - Williamson, Donald A.

AU - Wing, Rena R.

AU - Wyatt, Holly

AU - Yanovski, Susan Z.

AU - Zhang, Ping

N1 - Funding Information: This research was funded by the NIH through cooperative agreements with the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK): DK57136, DK57149, DK56990, DK57177, DK57171, DK57151, DK57182, DK57131, DK57002, DK57078, DK57154, DK57178, DK57219, DK57008, DK57135, and DK56992. Additional funding was provided by the National Heart, Lung, and Blood Institute, the National Institute of Nursing Research, the National Institute on Minority Health and Health Disparities, the NIH Office of Research on Women’s Health, and the Centers for Disease Control and Prevention. This research was supported in part by the Intramural Research Program of the NIDDK. The Indian Health Service provided personnel, medical oversight, and use of facilities. The opinions expressed in this article are those of the authors and do not necessarily reflect the views of the Indian Health Service or the other funding sources. Additional support was received from The Johns Hopkins Medical Institutions Bayview General Clinical Research Center (M01RR02719); the Massachusetts General Hospital Mallinckrodt General Clinical Research Center and the Massachusetts Institute of Technology General Clinical Research Center (M01RR01066); the Harvard Clinical and Translational Science Center (RR025758‐04); the University of Colorado Health Sciences Center General Clinical Research Center (M01RR00051) and Clinical Nutrition Research Unit (P30 DK48520); the University of Tennessee at Memphis General Clinical Research Center (M01RR0021140); the University of Pittsburgh General Clinical Research Center (M01RR000056) and the Clinical and Translational Research Center, funded by Clinical and Translational Science Award UL1 RR 024153 and NIH grant DK 046204; the US Department of Veterans Affairs Puget Sound Health Care System Medical Research Service; and the Frederic C. Bartter General Clinical Research Center (M01RR01346). The following organizations have committed to making major contributions to Look AHEAD: FedEx Corporation; Health Management Resources; LifeScan, Inc., a Johnson & Johnson Company; OPTIFAST of Nestle HealthCare Nutrition, Inc.; Hoffmann‐La Roche Inc.; Abbott Nutrition; and Slim‐Fast brand of Unilever, North America. AMC was supported, in part, by the National Institute of Nursing Research of the National Institutes of Health under Award Number K23NR017209. Funding Information: Look AHEAD data are available through the NIH/NIDDK Central Repository (https://repository.niddk.nih.gov/home/). These data sets include deidentified participant-level data. At this time, data are available beginning with the recruitment and randomization of participants (2001) through the end of the Look AHEAD intervention (2012) or for approximately 9 years of trial data on each participant. The study protocol, data collection forms, and data dictionaries are provided at this link. Requests for data are made through the NIDDK. Publisher Copyright: © 2020 The Obesity Society.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - OBJECTIVE: This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.METHODS: Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.RESULTS: Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean (SE) of 1.2 (0.2) kg and 1.8 (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.CONCLUSIONS: Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.

AB - OBJECTIVE: This study evaluated weight changes after cessation of the 10-year intensive lifestyle intervention (ILI) in the Look AHEAD (Action for Health in Diabetes) study. It was hypothesized that ILI participants would be more likely to gain weight during the 2-year observational period following termination of weight-loss-maintenance counseling than would participants in the diabetes support and education (DSE) control group.METHODS: Look AHEAD was a randomized controlled trial that compared the effects of ILI and DSE on cardiovascular morbidity and mortality in participants with overweight/obesity and type 2 diabetes. Look AHEAD was converted to an observational study in September 2012.RESULTS: Two years after the end of the intervention (EOI), ILI and DSE participants lost a mean (SE) of 1.2 (0.2) kg and 1.8 (0.2) kg, respectively (P = 0.003). In addition, 31% of ILI and 23.9% of DSE participants gained ≥ 2% (P < 0.001) of EOI weight, whereas 36.3% and 45.9% of the respective groups lost ≥ 2% of EOI weight (P = 0.001). Two years after the EOI, ILI participants reported greater use of weight-control behaviors than DSE participants.CONCLUSIONS: Both groups lost weight during the 2-year follow-up period, but more ILI than DSE participants gained ≥ 2% of EOI weight. Further understanding is needed of factors that affected long-term weight change in both groups.

KW - Aged

KW - Female

KW - Humans

KW - Life Style

KW - Male

KW - Middle Aged

KW - Obesity/therapy

KW - Weight Loss/physiology

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U2 - 10.1002/oby.22769

DO - 10.1002/oby.22769

M3 - Article

C2 - 32320144

AN - SCOPUS:85083652183

SN - 1930-7381

VL - 28

SP - 893

EP - 901

JO - Obesity

JF - Obesity

IS - 5

ER -

Weight Change 2 Years After Termination of the Intensive Lifestyle Intervention in the Look AHEAD Study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

Find It

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