TY - JOUR
T1 - Weight and length at birth and risk of early-onset prostate cancer (United States)
AU - Boland, Lori L.
AU - Mink, Pamela J.
AU - Bushhouse, Sally A.
AU - Folsom, Aaron R.
PY - 2003/5/1
Y1 - 2003/5/1
N2 - Objective: A case-control study was conducted to examine the association of weight and length at birth with early-onset prostate cancer. Methods: Cases of prostate cancer diagnosed between 1988 and 1995 (n = 192) were identified through the Minnesota Cancer Surveillance System. Two separate control groups were selected using driver's license (DL) and birth certificate (BC) listings. Results: Using the DL control group, an inverse association was observed between birth weight and prostate cancer risk; adjusted odds ratios (95% confidence intervals) for ≤3000, 3001-3500, 3501-4000, and >4000 g at birth were 1.0, 0.72 (0.4-1.28), 0.58 (0.31-1.10), and 0.49 (0.24-1.00). In analyses using the BC control group, adjusted odds ratios (95% CIs) for the aforementioned birth weight categories were 1.0, 1.18 (0.64-2.18), 0.80 (0.42-1.54), and 1.04 (0.48-2.26), respectively. For both control groups, adjusted odds ratios were somewhat elevated for the upper three categories of birth length, but all confidence intervals included the null value. Conclusions: These findings do not support the hypothesis that greater weight or length at birth increases risk of prostate cancer.
AB - Objective: A case-control study was conducted to examine the association of weight and length at birth with early-onset prostate cancer. Methods: Cases of prostate cancer diagnosed between 1988 and 1995 (n = 192) were identified through the Minnesota Cancer Surveillance System. Two separate control groups were selected using driver's license (DL) and birth certificate (BC) listings. Results: Using the DL control group, an inverse association was observed between birth weight and prostate cancer risk; adjusted odds ratios (95% confidence intervals) for ≤3000, 3001-3500, 3501-4000, and >4000 g at birth were 1.0, 0.72 (0.4-1.28), 0.58 (0.31-1.10), and 0.49 (0.24-1.00). In analyses using the BC control group, adjusted odds ratios (95% CIs) for the aforementioned birth weight categories were 1.0, 1.18 (0.64-2.18), 0.80 (0.42-1.54), and 1.04 (0.48-2.26), respectively. For both control groups, adjusted odds ratios were somewhat elevated for the upper three categories of birth length, but all confidence intervals included the null value. Conclusions: These findings do not support the hypothesis that greater weight or length at birth increases risk of prostate cancer.
KW - Birth length
KW - Birth weight
KW - Prostate cancer
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U2 - 10.1023/A:1023930318066
DO - 10.1023/A:1023930318066
M3 - Article
C2 - 12846364
AN - SCOPUS:0037701672
VL - 14
SP - 335
EP - 338
JO - Cancer Causes and Control
JF - Cancer Causes and Control
SN - 0957-5243
IS - 4
ER -