Weak ionic hydrogels. Effects of pH, ionic strength, and buffer composition on swelling equilibria, kinetics, and solute release

R. A. Siegel, B. A. Firestone, I. Johannes, J. Cornejo

Research output: Contribution to journalConference article

16 Scopus citations

Abstract

When the polymer contains ionizable groups, then the rate of polymer swelling and drug release is determined, at least partially, by the ionic environment. The authors report investigations of the swelling and release properties of glassy, hydrophobic gels consisting of poly(methyl methacrylate-co-N,N-dimethylaminoethyl methacrylate) (MMA/DMA). It is shown that swelling rates for such gels are sensitive not only to pH and ionic strength, but also of the precise buffer composition. It is also shown that for certain solutes incorporated into the dry gels, release is determined by the swelling rate. These results have implications regarding the swelling mechanism, and also bear on the potential of these gels as pH-sensitive drug carriers.

Original languageEnglish (US)
Pages (from-to)231-232
Number of pages2
JournalAmerican Chemical Society, Polymer Preprints, Division of Polymer Chemistry
Volume31
Issue number1
StatePublished - Apr 1 1990
EventPapers Presented at the Boston, Massachusetts Meeting of ACS 1989 - Boston, MA, USA
Duration: Apr 22 1989Apr 27 1989

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