waveCSD: A method for estimating transmembrane currents originated from propagating neuronal activity in the neocortex: Application to study cortical spreading depression

Arash Moshkforoush, Pedro A. Valdes-Hernandez, Daniel E. Rivera-Espada, Yoichiro Mori, Jorge Riera

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Recent years have witnessed an upsurge in the development of methods for estimating current source densities (CSDs) in the neocortical tissue from their recorded local field potential (LFP) reflections using microelectrode arrays. Among these, methods utilizing linear arrays work under the assumption that CSDs vary as a function of cortical depth; whereas they are constant in the tangential direction, infinitely or in a confined cylinder. This assumption is violated in the analysis of neuronal activity propagating along the neocortical sheet, e.g. propagation of alpha waves or cortical spreading depression. New method: Here, we developed a novel mathematical method (waveCSD) for CSD analysis of LFPs associated with a planar wave of neocortical neuronal activity propagating at a constant velocity towards a linear probe. Results: Results show that the algorithm is robust to the presence of noise in LFP data and uncertainties in knowledge of propagation velocity. Also, results show high level of accuracy of the method in a wide range of electrode resolutions. Using in vivo experimental recordings from the rat neocortex, we employed waveCSD to characterize transmembrane currents associated with cortical spreading depressions. Comparison with existing method(s): Simulation results indicate that waveCSD has a significantly higher reconstruction accuracy compared to the widely-used inverse CSD method (iCSD), and the regularized kernel CSD method (kCSD), in the analysis of CSDs originating from propagating neuronal activity. Conclusions: The waveCSD method provides a theoretical platform for estimation of transmembrane currents from their LFPs in experimental paradigms involving wave propagation.

Original languageEnglish (US)
Pages (from-to)106-124
Number of pages19
JournalJournal of Neuroscience Methods
Volume307
DOIs
StatePublished - Sep 1 2018

Bibliographical note

Funding Information:
This study was supported by the National Institutes of Health ( 1R56NS094784-01A1 ), the National Science Foundation ( DMS-1516176 and DMS-1516978 ), Ronald E McNair Post-baccalaureate Achievement Program (Daniel E. Rivera-Espada), and Coulter Undergraduate Research Excellence (CURE) Program at Florida International University (Daniel E. Rivera-Espada).

Publisher Copyright:
© 2018

Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.

Keywords

  • Cortical spreading depression
  • Current source density analysis
  • Local field potential
  • Wave propagation

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