Warts and cancer. The oncogenic potential of human papilloma virus

Peter J Lynch

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Papilloma viruses have a potential but seldom expressed carcinogenicity. It is found that the virions are lost in the process of viral oncogenesis and thereafter the electron-microscopy is useless. Only the use of new techniques of molecular hybridization, immunofluorescence for viral antigens and permissive co-cultures may indicate the presence of a viral DNA and will thus enable the identification of neoplasms caused by viruses. Among the papilloma viruses, only the types 3, 5 and 6, responsive for various flat warts and condylomata acuminatum, may be involved with oncogenic activity. The development of viral neoplasma needs also one or more co-carcinogen factors such as ultraviolet and X-rays, and first of all an immune-depressed (naturally or drug-induced) status. Renal transplant recipients, intensively treated with immunodepressants, are highly suggestive for this mechanism. Romania.

Original languageEnglish (US)
Pages (from-to)55-60
Number of pages6
JournalAmerican Journal of Dermatopathology
Issue number1
StatePublished - Dec 1 1982


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