Wallifoliol, a taxol congener with a novel carbon skeleton, from himalayan taxus wallichiana

David G. Vander Velde; Gunda I. Georg; Sitaraghav R. Gollapudi; Hanuman B. Jampani; Xiao Zhong Liang; Lester A. Mitscher; Qing Mei Ye

doi:10.1021/np50108a032

Wallifoliol, a taxol congener with a novel carbon skeleton, from himalayan taxus wallichiana

David G. Vander Velde, Gunda I. Georg, Sitaraghav R. Gollapudi, Hanuman B. Jampani, Xiao Zhong Liang, Lester A. Mitscher, Qing Mei Ye

Medicinal Chemistry

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Abstract

A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol=taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.

Original language	English (US)
Pages (from-to)	862-867
Number of pages	6
Journal	Journal of Natural Products
Volume	57
Issue number	6
DOIs	https://doi.org/10.1021/np50108a032
State	Published - Jun 1 1994

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title = "Wallifoliol, a taxol congener with a novel carbon skeleton, from himalayan taxus wallichiana",

abstract = "A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol=taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.",

author = "{Vander Velde}, {David G.} and Georg, {Gunda I.} and Gollapudi, {Sitaraghav R.} and Jampani, {Hanuman B.} and Liang, {Xiao Zhong} and Mitscher, {Lester A.} and Ye, {Qing Mei}",

year = "1994",

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doi = "10.1021/np50108a032",

language = "English (US)",

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T1 - Wallifoliol, a taxol congener with a novel carbon skeleton, from himalayan taxus wallichiana

AU - Vander Velde, David G.

AU - Georg, Gunda I.

AU - Gollapudi, Sitaraghav R.

AU - Jampani, Hanuman B.

AU - Liang, Xiao Zhong

AU - Mitscher, Lester A.

AU - Ye, Qing Mei

PY - 1994/6/1

Y1 - 1994/6/1

N2 - A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol=taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.

AB - A new taxoid, wallifoliol [3], has been isolated, along with five known taxoids (taxol, cephalomannine, 10-deacetylbaccatin III, brevifoliol, 2-acetoxy brevifoliol=taxchinin A) from extracts of the needles of Himalayan Taxus wallichiana. The structure of wallifoliol has been assigned primarily from nmr studies. Wallifoliol [3] is assigned a structure in which rings A and B of the taxane system have undergone putative rearrangements producing a novel skeleton. Wallifoliol is the first diterpene to be found in nature with this particular 5/6/6/6/4 ring system.

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Wallifoliol, a taxol congener with a novel carbon skeleton, from himalayan taxus wallichiana

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