Walden-inversion-enforced transition-state stabilization in a protein tyrosine phosphatase

Keyphrases

• Dephosphorylation 100%
• Protein Tyrosine Phosphatase 1B (PTP1B) 100%
• Transition State Stabilization 100%
• Walden Inversion 100%
• Phosphate 66%
• Tyrosine 33%
• Molecular Dynamics Simulation 33%
• Analysis Support 33%
• Quantum Mechanical 33%
• Low Molecular Weight 33%
• Transition State 33%
• Hydrogen Bonding Interaction 33%
• Dianion 33%
• Kinetic Experiments 33%
• Activation Free Energy 33%
• Activation Parameters 33%
• Monoanion 33%
• Stopped-flow Kinetics 33%
• Mechanical Approach 33%
• Mechanistic Proposals 33%

Biochemistry, Genetics and Molecular Biology

• Dephosphorylation 100%
• Protein Tyrosine Phosphatase 100%
• Tyrosine 33%
• Stopped-Flow Kinetics 33%
• Enzyme 33%
• Molecular Weight 33%