Waking up T cells to counteract chronic infections

Barry T. Rouse, David Masopust

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations


Memory T-cell responses generated in chronic viral infections can show functional defects contributing to poor viral control. Recently, signaling through the PD-1 receptor on CD8+ T cells was shown to cause cells to express an exhausted phenotype in an animal model of chronic infection. By blocking the interaction of PD-1 with its ligand PD-L1, virus-specific CD8+ T cells exhibited expansion and improved infection control. This approach could prove valuable to manage chronic infections.

Original languageEnglish (US)
Pages (from-to)205-207
Number of pages3
JournalTrends in Immunology
Issue number5
StatePublished - May 1 2006

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