Waking up T cells to counteract chronic infections

Barry T. Rouse; David Masopust

doi:10.1016/j.it.2006.03.008

Waking up T cells to counteract chronic infections

Barry T. Rouse, David Masopust

Microbiology

Research output: Contribution to journal › Short survey › peer-review

4 Scopus citations

Abstract

Memory T-cell responses generated in chronic viral infections can show functional defects contributing to poor viral control. Recently, signaling through the PD-1 receptor on CD8⁺ T cells was shown to cause cells to express an exhausted phenotype in an animal model of chronic infection. By blocking the interaction of PD-1 with its ligand PD-L1, virus-specific CD8⁺ T cells exhibited expansion and improved infection control. This approach could prove valuable to manage chronic infections.

Original language	English (US)
Pages (from-to)	205-207
Number of pages	3
Journal	Trends in Immunology
Volume	27
Issue number	5
DOIs	https://doi.org/10.1016/j.it.2006.03.008
State	Published - May 1 2006

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abstract = "Memory T-cell responses generated in chronic viral infections can show functional defects contributing to poor viral control. Recently, signaling through the PD-1 receptor on CD8+ T cells was shown to cause cells to express an exhausted phenotype in an animal model of chronic infection. By blocking the interaction of PD-1 with its ligand PD-L1, virus-specific CD8+ T cells exhibited expansion and improved infection control. This approach could prove valuable to manage chronic infections.",

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AB - Memory T-cell responses generated in chronic viral infections can show functional defects contributing to poor viral control. Recently, signaling through the PD-1 receptor on CD8+ T cells was shown to cause cells to express an exhausted phenotype in an animal model of chronic infection. By blocking the interaction of PD-1 with its ligand PD-L1, virus-specific CD8+ T cells exhibited expansion and improved infection control. This approach could prove valuable to manage chronic infections.

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