Abstract
Memory T-cell responses generated in chronic viral infections can show functional defects contributing to poor viral control. Recently, signaling through the PD-1 receptor on CD8+ T cells was shown to cause cells to express an exhausted phenotype in an animal model of chronic infection. By blocking the interaction of PD-1 with its ligand PD-L1, virus-specific CD8+ T cells exhibited expansion and improved infection control. This approach could prove valuable to manage chronic infections.
Original language | English (US) |
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Pages (from-to) | 205-207 |
Number of pages | 3 |
Journal | Trends in Immunology |
Volume | 27 |
Issue number | 5 |
DOIs | |
State | Published - May 2006 |