Vulvar histology after neutral red photoinactivation of herpes simplex virus

Eduard G. Friedrich, Raymond H. Kaufman, Peter J. Lynch, J. Donald Woodruff

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The use of photodynamic dye and light inactivation for the treatment of genital herpes simplex vims infections has been associated with the risk of potential oncogenesis. Sixteen patients treated with neutral red and fluorescent light for documented herpetic infections were studied at intervals ranging from 9 to 52 months following treatment. Four patients treated with other modalities were included in the study. Biopsies of the treated areas were obtained, and 3925 tissue sections were examined. Mild atypical epithelial changes were focally present in most specimens regardless of therapy. Histologically identifiable premalignant change could not be demonstrated.

Original languageEnglish (US)
Pages (from-to)564-570
Number of pages7
JournalObstetrics and gynecology
Issue number5
StatePublished - Nov 1976
Externally publishedYes


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