Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia

Kelvin O. Lim, Babak A. Ardekani, J. Nierenberg, Pamela D. Butler, Daniel C. Javitt, Matthew J. Hoptman

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Patients with schizophrenia show deficits in several neurocognitive domains. However, the relationship between white matter integrity and performance in these domains is poorly understood. The authors conducted neurocognitive testing and diffusion tensor imaging in 25 patients with schizophrenia. Performance was examined for tests of verbal declarative memory, attention, and executive function. Relationships between fractional anisotropy and cognitive performance were examined by using voxelwise correlational analyses. In each case, better performance on these tasks was associated with higher levels of fractional anisotropy in task-relevant regions.

Original languageEnglish (US)
Pages (from-to)2008-2010
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number11
DOIs
StatePublished - Nov 2006

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